A novel nanoparticle for improving the photodynamic effect of tumor anoxic environment
文献类型：会议论文
| 作者 | Zhenguo Liang; Ping Gong; Qian Ren; Lintao Cai; Wenjun Li; Zhihong Sun; Xinghua Peng; Jiazheng Lai; Xiaoqing Meng; Zhen Xu |
| 出版日期 | 2018 |
| 会议日期 | 2018 |
| 会议地点 | 上海 |
| 英文摘要 | Photodynamic therapy (PDT) is one of the effective anticancer treatment strategies, but the natural hypoxic tumor microenvironment and hypoxia supply are the main obstacles for its further application, so the oxygen increase at the tumor site is significant.Based on our previous synthesized tumor-targeting hyaluronidase activatable nanoparticles (HA-Ce6) by covalent conjugating chlorin e6 (Ce6) and hyaluronic acid (HA), we combined HA-Ce6 and oxygen supply carrier hemoglobin (Hb) through click chemistry to boost photodynamic efficiency of Ce6. The resulting nanoparticles HA-Ce6-Hb could efficiently reach the tumor tissue through the passive targeting strategies and specifically enter tumor cells via binding of HA to CD44, which is an HA receptor overexpressed on tumor cells.Then the nanoparticles can effective release Ce6 by hyaluronidase in tumor microenvironment. Upon exposure to near-infrared laser, the released Ce6 can generate a large amount of cytotoxic reactive oxygen species (ROS) with sufficient oxygen supply.Moreover, the nanoparticles HA-Ce6-Hb spontaneously act as an ideal fluorescent/photoacoustic (FL/PA) dual-modality imaging probe, dynamically monitoring the photosensitizer/oxygen metabolism and consumption, which could be successfully applied to in vivo tumor imaging and photodynamic therapy simultaneously. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14751]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Zhenguo Liang,Ping Gong,Qian Ren,et al. A novel nanoparticle for improving the photodynamic effect of tumor anoxic environment[C]. 见:. 上海. 2018. |
入库方式： OAI收割
来源：深圳先进技术研究院
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