Rhizopus nigricans polysaccharide activated macrophages and suppressed tumor growth in CT26 tumor-bearing mice
文献类型：期刊论文
| 作者 | Zhang, Linan; Wei, Zhihong; Chen, Guochuang; Zhang, Pengying; Zhu, Lei; Chen, Kaoshan |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | In this study, a homogeneous polysaccharide (RPS-1) was extracted from liquid-cultured mycelia of Rhizopus nigricans. The weight-average molecular weight of RPS-1 was 1.617 x 10(7) g/mol and structural characterization indicated that RPS-1 was a non-starch glucan which consisted of a backbone structure of (1 -> 4)-linked alpha-D-glucopyranosyl residues substituted at the O-6 position with alpha-D-glucopyranosyl branches. RPS-1 stimulated the production of nitric oxide and tumor necrosis factor-alpha by triggering phosphorylation of mitogen-activated protein kinases and nuclear translocation of nuclear factor kappa B p65 in RAW 264.7 macrophage cells. Moreover, intragastric administration of RPS-1 improved the immune function of CT26 tumor-bearing mice and significantly inhibited the growth of transplanted tumor. In combination with 5-FU, RPS-1 enhanced antitumor activity of 5-FU and alleviated its toxicity on immune system. These findings suggested that RPS-1 has the potential for the development of functional foods and dietary supplements. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14846]  |
| 专题 | 深圳先进技术研究院_其他 |
| 推荐引用方式 GB/T 7714 | Zhang, Linan,Wei, Zhihong,Chen, Guochuang,et al. Rhizopus nigricans polysaccharide activated macrophages and suppressed tumor growth in CT26 tumor-bearing mice[J]. CARBOHYDRATE POLYMERS,2018. |
| APA | Zhang, Linan,Wei, Zhihong,Chen, Guochuang,Zhang, Pengying,Zhu, Lei,&Chen, Kaoshan.(2018).Rhizopus nigricans polysaccharide activated macrophages and suppressed tumor growth in CT26 tumor-bearing mice.CARBOHYDRATE POLYMERS. |
| MLA | Zhang, Linan,et al."Rhizopus nigricans polysaccharide activated macrophages and suppressed tumor growth in CT26 tumor-bearing mice".CARBOHYDRATE POLYMERS (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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