Novel 4-Hydroxycoumarin Derivatives: Anti-Cancer Effects on Human Oral Cancer Cells
文献类型：期刊论文
| 作者 | Gao, Jun; Ding, Zhenhua; Feng, Hongtao; Gao, Lin; Li, Shanshan |
| 刊名 | LATIN AMERICAN JOURNAL OF PHARMACY
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The reaction of 4-hydroxycoumarin with aromatic aldehyde (or malononitrile) gave two kinds of 4-hydroxycoumarin derivatives (1-8) and their structures were characterized via IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. The in vitro anticancer activity of the synthesized products was studied and evaluated, in which four human oral cancer cell liness (HB, CNE-1, SAS and HSQ-89) were used in the screening tests. The results showed that compared with compounds 5-8, compounds 1-4 with intramolecular hydrogen bonds exerted rather potent activity. In addition, the relationship between activity and structure of compounds 14 was further investigated through molecular docking study. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14852]  |
| 专题 | 深圳先进技术研究院_其他 |
| 推荐引用方式 GB/T 7714 | Gao, Jun,Ding, Zhenhua,Feng, Hongtao,et al. Novel 4-Hydroxycoumarin Derivatives: Anti-Cancer Effects on Human Oral Cancer Cells[J]. LATIN AMERICAN JOURNAL OF PHARMACY,2018. |
| APA | Gao, Jun,Ding, Zhenhua,Feng, Hongtao,Gao, Lin,&Li, Shanshan.(2018).Novel 4-Hydroxycoumarin Derivatives: Anti-Cancer Effects on Human Oral Cancer Cells.LATIN AMERICAN JOURNAL OF PHARMACY. |
| MLA | Gao, Jun,et al."Novel 4-Hydroxycoumarin Derivatives: Anti-Cancer Effects on Human Oral Cancer Cells".LATIN AMERICAN JOURNAL OF PHARMACY (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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