OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells
文献类型：期刊论文
| 作者 | Huang, Weiren; Wang, Dailian; Chen, Zhicong; Lin, Fan; Wang, Ziqiang; Gao, Qunjun; Xie, Haibiao; Xiao, Huizhong; Zhou, Yifan; Zhang, Fuyou |
| 刊名 | JOURNAL OF CANCER
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Opa interacting protein 5 (OIP5) has previously been identified as a tumorigenesis gene. The purpose of this study is to explore the role of OIP5 in the progression of bladder cancer (BC). The OIP5 expression and clinical behaviors in bladder cancer were collected from lager database. Our study showed that OIP5 was highly expressed in bladder cancer tissues and cells. Overexpression of OIP5 in tumor patients predicted worse overall survival (OS) and higher histological grade. Vitro and vivo experiments demonstrated that knockdown of OIP5 significantly inhibited cell growth of BC. Scratch assay and transwell assay suggested that migration capacity of BC cells was decreased after knockdown of OIP5. Cisplatin sensitivity assay indicated that depletion of OIP5increased the sensitivity of BC cells to cisplatin. Finally, we identified 38 overlapping differentially expressed genes (DEGs) between RNA-seq and TCGA analyses which were closely linked to OIP5. Bioinformatics analysis showed that these DEGs enriched in oocyte meiosis, fanconi anemia pathway, cell cycle, and microRNAs regulation. TOP2A, SPAG5, SKA1, EXO1, TK1 were confirmed to associated with bladder cancer development. Our study suggests that OIP5may be a potential biomarker for growth, metastasis and drug-resistance in bladder cancer. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14891]  |
| 专题 | 深圳先进技术研究院_其他 |
| 推荐引用方式 GB/T 7714 | Huang, Weiren,Wang, Dailian,Chen, Zhicong,et al. OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells[J]. JOURNAL OF CANCER,2018. |
| APA | Huang, Weiren.,Wang, Dailian.,Chen, Zhicong.,Lin, Fan.,Wang, Ziqiang.,...&Liu, Yuchen.(2018).OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells.JOURNAL OF CANCER. |
| MLA | Huang, Weiren,et al."OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells".JOURNAL OF CANCER (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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