In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration
文献类型：期刊论文
| 作者 | Qu, Songnan; Bao, Xin; Yuan, Ye; Chen, Jingqin; Zhang, Bohan; Li, Di; Zhou, Ding; Jing, Pengtao; Xu, Guiying; Wang, Yingli |
| 刊名 | LIGHT-SCIENCE & APPLICATIONS
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Carbon dots that exhibit near-infrared fluorescence (NIR CDs) are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents. Despite progress in the synthesis of NIR CDs, there remains a key obstacle to using them as an in vivo theranostic agent. This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy (PTT) in mouse models (conversion efficiency of 59%) and can be readily visualized by photoluminescence and photoacoustic imaging. The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting. Contrary to all other nanomaterials that have been tested in biomedicine, they are excreted through the body's renal filtration system. Moreover, after intravenous injection, NIR CDs are accumulated in tumor tissue via passive targeting, without any active species such as antibodies. Due to their accumulation in tumor tissue without the need for intratumor injection, high photothermal conversion, excel lent optical and photoacoustic imaging performance, and renal excretion, the developed CDs are suitable for transfer to clinical biomedical practice. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14894]  |
| 专题 | 深圳先进技术研究院_其他 |
| 推荐引用方式 GB/T 7714 | Qu, Songnan,Bao, Xin,Yuan, Ye,et al. In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration[J]. LIGHT-SCIENCE & APPLICATIONS,2018. |
| APA | Qu, Songnan.,Bao, Xin.,Yuan, Ye.,Chen, Jingqin.,Zhang, Bohan.,...&Zboril, Radek.(2018).In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration.LIGHT-SCIENCE & APPLICATIONS. |
| MLA | Qu, Songnan,et al."In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration".LIGHT-SCIENCE & APPLICATIONS (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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