Structural modularity and grid activity in the medial entorhinal cortex
文献类型：期刊论文
| 作者 | Robert K. Naumann; Andrea Burgalossi; Michael Brecht; Patricia Preston-Ferrer |
| 刊名 | Journal of neurophysiology
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Following the groundbreaking discovery of grid cells, the medial entorhinal cortex (MEC) has become the focus of intense anatomical, physiological, and computational investigations. Whether and how grid activity maps onto cell types and cortical architecture is still an open question. Fundamental similarities in microcircuits, function, and connectivity suggest a homology between rodent MEC and human posteromedial entorhinal cortex. Both are specialized for spatial processing and display similar cellular organization, consisting of layer 2 pyramidal/calbindin cell patches superimposed on scattered stellate neurons. Recent data indicate the existence of a further nonoverlapping modular system (zinc patches) within the superficial MEC layers. Zinc and calbindin patches have been shown to receive largely segregated inputs from the presubiculum and parasubiculum. Grid cells are also clustered in the MEC, and we discuss possible structure-function schemes on how grid activity could map onto cortical patch systems. We hypothesize that in the superficial layers of the MEC, anatomical location can be predictive of function; thus relating functional properties and neuronal morphologies to the cortical modules will be necessary for resolving how grid activity maps onto cortical architecture. Imaging or cell identification approaches in freely moving animals will be required for testing this hypothesis. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/13868]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 推荐引用方式 GB/T 7714 | Robert K. Naumann,Andrea Burgalossi,Michael Brecht,et al. Structural modularity and grid activity in the medial entorhinal cortex[J]. Journal of neurophysiology,2018. |
| APA | Robert K. Naumann,Andrea Burgalossi,Michael Brecht,&Patricia Preston-Ferrer.(2018).Structural modularity and grid activity in the medial entorhinal cortex.Journal of neurophysiology. |
| MLA | Robert K. Naumann,et al."Structural modularity and grid activity in the medial entorhinal cortex".Journal of neurophysiology (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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