Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish
文献类型：期刊论文
| 作者 | Chan, Matthew T., V; Peng, Gang; Zhang, Quan; Cheng, Christopher H. K.; Xie, Yuxin; Zhu, Zeyao; Liu, Taian; Shi, Yujian; Sun, Xiao; Wu, William K. K. |
| 刊名 | TRANSLATIONAL PSYCHIATRY
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Susceptible genetic polymorphisms and altered expression levels of protein kinase C (PKC)-encoding genes suggest overactivation of PKC in autism spectrum disorder (ASD) development. To delineate the pathological role of PKC, we pharmacologically stimulated its activity during the early development of zebrafish. Results demonstrated that PKC hyper-activation perturbs zebrafish development and induces a long-lasting head size deficit. The anatomical and cellular analysis revealed reduced neural precursor proliferation and newborn neuron formation. beta-Catenin that is essential for brain growth is dramatically degraded. Stabilization of beta-catenin by gsk3 beta inhibition partially restores the head size deficit. In addition, the neuropathogenic effect of developmental PKC hyper-activation was further supported by the alterations in the behavioral domain including motor abnormalities, heightened stress reactivity and impaired habituation learning. Taken together, by causally connecting early-life PKC hyper-activation to these neuropathological traits and the impaired neurogenesis, these results suggest that PKC could be a critical pathway in ASD pathogenesis. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/13879]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 推荐引用方式 GB/T 7714 | Chan, Matthew T., V,Peng, Gang,Zhang, Quan,et al. Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish[J]. TRANSLATIONAL PSYCHIATRY,2018. |
| APA | Chan, Matthew T., V.,Peng, Gang.,Zhang, Quan.,Cheng, Christopher H. K..,Xie, Yuxin.,...&Sham, Kathy W. Y..(2018).Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish.TRANSLATIONAL PSYCHIATRY. |
| MLA | Chan, Matthew T., V,et al."Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish".TRANSLATIONAL PSYCHIATRY (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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