Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies
文献类型：期刊论文
| 作者 | Amy K.Y. Fu; Yu Chen; Nancy Y. Ip |
| 刊名 | PHARMACOLOGY & THERAPEUTICS
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the elderly population, is characterized by progressive cognitive decline and pathological hallmarks of amyloid plaques and neurofibrillary tangles. However, its pathophysiological mechanisms are poorly understood, and diagnostic tools and interventions are limited. Here, we review recent research on the amyloid hypothesis and beta-amyloid–induced dysfunction of neuronal synapses through distinct cell surface receptors. We also review how tau protein leads to synaptotoxicity through pathological modification, localization, and propagation. Finally, we discuss experimental therapeutics for AD and propose potential applications of disease-modifying strategies targeting synaptic failure for improved treatment of AD. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/13880]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 推荐引用方式 GB/T 7714 | Amy K.Y. Fu,Yu Chen,Nancy Y. Ip. Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies[J]. PHARMACOLOGY & THERAPEUTICS,2018. |
| APA | Amy K.Y. Fu,Yu Chen,&Nancy Y. Ip.(2018).Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies.PHARMACOLOGY & THERAPEUTICS. |
| MLA | Amy K.Y. Fu,et al."Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies".PHARMACOLOGY & THERAPEUTICS (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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