Dynamic Salience Processing in Paraventricular Thalamus Gates Associative Learning.
文献类型：期刊论文
| 作者 | Yingjie Zhu; Xiaoke Chen; Liqun Luo; William E. Allen; Piper C. Keyes; Gregory Nachtrab |
| 刊名 | Science
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The salience of behaviorally relevant stimuli is dynamic and influenced by internal state and external environment. Monitoring such changes is critical for effective learning and flexible behavior, but the neuronal substrate for tracking the dynamics of stimulus salience is obscure.We found that neurons in the paraventricular thalamus (PVT) are robustly activated by a variety of behaviorally relevant events, including novel (“unfamiliar”) stimuli, reinforcing stimuli and their predicting cues, as well as omission of the expected reward. PVT responses are scaled with stimulus intensity and modulated by changes in homeostatic state or behavioral context. Inhibition of the PVT responses suppresses appetitive or aversive associative learning and reward extinction. Our findings demonstrate that the PVT gates associative learning by providing a dynamic representation of stimulus salience. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/13881]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 推荐引用方式 GB/T 7714 | Yingjie Zhu,Xiaoke Chen,Liqun Luo,et al. Dynamic Salience Processing in Paraventricular Thalamus Gates Associative Learning.[J]. Science,2018. |
| APA | Yingjie Zhu,Xiaoke Chen,Liqun Luo,William E. Allen,Piper C. Keyes,&Gregory Nachtrab.(2018).Dynamic Salience Processing in Paraventricular Thalamus Gates Associative Learning..Science. |
| MLA | Yingjie Zhu,et al."Dynamic Salience Processing in Paraventricular Thalamus Gates Associative Learning.".Science (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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