A human gut phage catalog correlates the gut phageome with type 2 diabetes.
文献类型：期刊论文
| 作者 | Tokuyasu, Taku; Ma, Yingfei; You, Xiaoyan; Mai, Guoqin; Liu, Chenli |
| 刊名 | MICROBIOME
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Background: Substantial efforts have been made to link the gut bacterial community to many complex human diseases. Nevertheless, the gut phages are often neglected. Results: In this study, we used multiple bioinformatic methods to catalog gut phages from whole-community metagenomic sequencing data of fecal samples collected from both type II diabetes (T2D) patients (n = 71) and normal Chinese adults (n = 74). The definition of phage operational taxonomic units (pOTUs) and identification of large phage scaffolds (n = 2567, = 10 k) revealed a comprehensive human gut phageome with a substantial number of novel sequences encoding genes that were unrelated to those in known phages. Interestingly, we observed a significant increase in the number of gut phages in the T2D group and, in particular, identified 7 pOTUs specific to T2D. This finding was further validated in an independent dataset of 116 T2D and 109 control samples. Co-occurrence/exclusion analysis of the bacterial genera and pOTUs identified a complex core interaction between bacteria and phages in the human gut ecosystem, suggesting that the significant alterations of the gut phageome cannot be explained simply by co-variation with the altered bacterial hosts. Conclusions: Alterations in the gut bacterial community have been linked to the chronic disease T2D, but the role of gut phages therein is not well understood. This is the first study to identify a T2D-specific gut phageome, indicating the existence of other mechanisms that might govern the gut phageome in T2D patients. These findings suggest the importance of the phageome in T2D risk, which warrants further investigation. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/13417]  |
| 专题 | 合成所 |
| 推荐引用方式 GB/T 7714 | Tokuyasu, Taku,Ma, Yingfei,You, Xiaoyan,et al. A human gut phage catalog correlates the gut phageome with type 2 diabetes.[J]. MICROBIOME,2018. |
| APA | Tokuyasu, Taku,Ma, Yingfei,You, Xiaoyan,Mai, Guoqin,&Liu, Chenli.(2018).A human gut phage catalog correlates the gut phageome with type 2 diabetes..MICROBIOME. |
| MLA | Tokuyasu, Taku,et al."A human gut phage catalog correlates the gut phageome with type 2 diabetes.".MICROBIOME (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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