Capturing the interactome of newly transcribed RNA.
文献类型：期刊论文
| 作者 | Zhang, Gong; Bao, Xichen; Guo, Xiangpeng; Yin, Menghui; Tariq, Muqddas; Lai, Yiwei; Kanwal, Shahzina; Zhou, Jiajian; Li, Na; Lv, Yuan |
| 刊名 | NATURE METHODS
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | We combine the labeling of newly transcribed RNAs with 5-ethynyluridine with the characterization of bound proteins. This approach, named capture of thenewly transcribed RNA interactome using click chemistry (RICK), systematically captures proteins bound to a wide range of RNAs, including nascent RNAs and traditionally neglected nonpolyadenylated RNAs. RICK has identified mitotic regulators amongst other novel RNA-binding proteins with preferential affinity for nonpolyadenylated RNAs, revealed a link between metabolic enzymes/factors and nascent RNAs, and expanded the known RNA-bound proteome of mouse embryonic stem cells. RIC K will facilitate an in-depth interrogation of the total RNA-bound proteome in different cells and systems. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/13418]  |
| 专题 | 合成所 |
| 推荐引用方式 GB/T 7714 | Zhang, Gong,Bao, Xichen,Guo, Xiangpeng,et al. Capturing the interactome of newly transcribed RNA.[J]. NATURE METHODS,2018. |
| APA | Zhang, Gong.,Bao, Xichen.,Guo, Xiangpeng.,Yin, Menghui.,Tariq, Muqddas.,...&Esteban, Miguel A..(2018).Capturing the interactome of newly transcribed RNA..NATURE METHODS. |
| MLA | Zhang, Gong,et al."Capturing the interactome of newly transcribed RNA.".NATURE METHODS (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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