Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
文献类型：期刊论文
| 作者 | Baidoo, Edward E. K.; Yuzawa, Satoshi; Mirsiaghi, Mona; Jocic, Renee; Fujii, Tatsuya; Masson, Fabrice; Benites, Veronica T.; Sundstrom, Eric; Tanjore, Deepti; Pray, Todd R. |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Microbial production of fuels and commodity chemicals has been performed primarily using natural or slightly modified enzymes, which inherently limits the types of molecules that can be produced. Type I modular polyketide synthases (PKSs) are multi-domain enzymes that can produce unique and diverse molecular structures by combining particular types of catalytic domains in a specific order. This catalytic mechanism offers a wealth of engineering opportunities. Here we report engineered microbes that produce various short-chain (C5-C7) ketones using hybrid PKSs. Introduction of the genes into the chromosome of Streptomyces albus enables it to produce >1 g . l(-1) of C6 and C7 ethyl ketones and several hundred mg . l(-1) of C5 and C6 methyl ketones from plant biomass hydrolysates. Engine tests indicate these short-chain ketones can be added to gasoline as oxygenates to increase the octane of gasoline. Together, it demonstrates the efficient and renewable microbial production of biogasolines by hybrid enzymes. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/13435]  |
| 专题 | 合成所 |
| 推荐引用方式 GB/T 7714 | Baidoo, Edward E. K.,Yuzawa, Satoshi,Mirsiaghi, Mona,et al. Short-chain ketone production by engineered polyketide synthases in Streptomyces albus[J]. NATURE COMMUNICATIONS,2018. |
| APA | Baidoo, Edward E. K..,Yuzawa, Satoshi.,Mirsiaghi, Mona.,Jocic, Renee.,Fujii, Tatsuya.,...&Keasling, Jay D..(2018).Short-chain ketone production by engineered polyketide synthases in Streptomyces albus.NATURE COMMUNICATIONS. |
| MLA | Baidoo, Edward E. K.,et al."Short-chain ketone production by engineered polyketide synthases in Streptomyces albus".NATURE COMMUNICATIONS (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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