Whole genome engineering by synthesis
文献类型：期刊论文
| 作者 | Dai, Junbiao; Luo, Zhouqing; Yang, Qing; Geng, Binan; Jiang, Shuangying; Yang, Shihui; Li, Xiaozheng; Cai, Yizhi |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Whole genome engineering is now feasible with the aid of genome editing and synthesis tools. Synthesizing a genome from scratch allows modifications of the genomic structure and function to an extent that was hitherto not possible, which will finally lead to new insights into the basic principles of life and enable valuable applications. With several recent genome synthesis projects as examples, the technical details to synthesize a genome and applications of synthetic genome are addressed in this perspective. A series of ongoing or future synthetic genomics projects, including the different genomes to be synthesized in GPwrite, synthetic minimal genome, massively recoded genome, chimeric genome and synthetic genome with expanded genetic alphabet, are also discussed here with a special focus on theoretical and technical impediments in the design and synthesis process. Synthetic genomics will become a commonplace to engineer pathways and genomes according to arbitrary sets of design principles with the development of high-efficient, low-cost genome synthesis and assembly technologies. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/13440]  |
| 专题 | 合成所 |
| 推荐引用方式 GB/T 7714 | Dai, Junbiao,Luo, Zhouqing,Yang, Qing,et al. Whole genome engineering by synthesis[J]. SCIENCE CHINA-LIFE SCIENCES,2018. |
| APA | Dai, Junbiao.,Luo, Zhouqing.,Yang, Qing.,Geng, Binan.,Jiang, Shuangying.,...&Cai, Yizhi.(2018).Whole genome engineering by synthesis.SCIENCE CHINA-LIFE SCIENCES. |
| MLA | Dai, Junbiao,et al."Whole genome engineering by synthesis".SCIENCE CHINA-LIFE SCIENCES (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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