JNK1/2 and ERK1/2 provides vital clues about tumor recurrence and survival in hepatocellular carcinoma patients.
文献类型：期刊论文
| 作者 | Xiaoge Gao; Wenhua Shan; Xiangye Liu; Jian Zhang; Junnian Zheng; Hong Yao |
| 刊名 | FUTURE ONCOLOGY
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | AIM: To explore JNK1/2 and ERK1/2 activation in hepatocellular carcinoma (HCC) patients. PATIENTS & METHODS: Phosphorylated-JNK1/2 and -ERK1/2 (p-JNK1/2 and p-ERK1/2) expressions were determined and analyzed in 104 unique HCC tissue specimens. RESULTS: Expression of p-JNK1/2 and p-ERK1/2 was not correlated with clinicopathological characteristics. High p-JNK1/2 and low p-ERK1/2 expressions predicated significantly lower tumor recurrence for HCC patients. However, HCC patients with low p-JNK1/2 and high p-ERK1/2 had higher tumor recurrence. Moreover, p-JNK1/2 positively, but p-ERK1/2 negatively, associated with overall survival (OS) and recurrence-free survival (RFS) in HCC patients. In addition, HCC patients with simultaneous low p-JNK1/2 and high p-ERK1/2 had poorer OS and RFS. On the contrary, patients with high p-JNK1/2 and low p-ERK1/2 presented better OS and RFS. CONCLUSION: HCC patients with low p-JNK1/2 and high p-ERK1/2 either independently or simultaneously, had significantly higher tumor recurrence and worse OS. KEYWORDS: hepatocellular carcinoma; phosphorylated ERK1/2; phosphorylated JNK1/2 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/13455]  |
| 专题 | 合成所 |
| 推荐引用方式 GB/T 7714 | Xiaoge Gao,Wenhua Shan,Xiangye Liu,et al. JNK1/2 and ERK1/2 provides vital clues about tumor recurrence and survival in hepatocellular carcinoma patients.[J]. FUTURE ONCOLOGY,2018. |
| APA | Xiaoge Gao,Wenhua Shan,Xiangye Liu,Jian Zhang,Junnian Zheng,&Hong Yao.(2018).JNK1/2 and ERK1/2 provides vital clues about tumor recurrence and survival in hepatocellular carcinoma patients..FUTURE ONCOLOGY. |
| MLA | Xiaoge Gao,et al."JNK1/2 and ERK1/2 provides vital clues about tumor recurrence and survival in hepatocellular carcinoma patients.".FUTURE ONCOLOGY (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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