Age Is Important for the Early-Stage Detection of Breast Cancer on Both Transcriptomic and Methylomic Biomarkers
文献类型:期刊论文
作者 | Feng, X (Feng, Xin)[ 1,2 ]; Li, JL (Li, Jialiang)[ 2,3 ]; Li, H (Li, Han)[ 2,3 ]; Chen, H (Chen, Hang)[ 1,2 ]; Li, F (Li, Fei)[ 2,3 ]; Liu, QW (Liu, Quewang)[ 1,2 ]; You, ZH (You, Zhu-Hong)[ 4 ]; Zhou, FF (Zhou, Fengfeng)[ 1,2,3 ] |
刊名 | FRONTIERS IN GENETICS |
出版日期 | 2019 |
卷号 | 10期号:3页码:1-13 |
ISSN号 | 1664-8021 |
关键词 | age feature selection TriVote BRCA classification transcriptome methylome |
DOI | 10.3389/fgene.2019.00212 |
英文摘要 | Patients at different ages have different rates of cell development and metabolisms. As a result, age should be an essential part of how a disease diagnosis model is trained and optimized. Unfortunately, most of the existing studies have not taken age into account. This study demonstrated that disease diagnosis models could be improved by merely applying individual models for patients of different age groups. Both transcriptomes and methylomes of the TCGA breast cancer dataset (TCGA-BRCA) were utilized for the analysis procedure of feature selection and classification. Our experimental data strongly suggested that disease diagnosis modeling should integrate patient age into the whole experimental design. |
WOS记录号 | WOS:000462596600001 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/5707] |
专题 | 新疆理化技术研究所_多语种信息技术研究室 |
作者单位 | 1.Jilin Univ, Coll Comp Sci & Technol, BioKnow Hlth Informat Lab, Changchun, Jilin, Peoples R China 2.Jilin Univ, Minist Educ, Key Lab Symbol Computat & Knowledge Engn, Changchun, Jilin, Peoples R China 3.Jilin Univ, Coll Software, BioKnow Hlth Informat Lab, Changchun, Jilin, Peoples R China 4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China |
推荐引用方式 GB/T 7714 | Feng, X ,Li, JL ,Li, H ,et al. Age Is Important for the Early-Stage Detection of Breast Cancer on Both Transcriptomic and Methylomic Biomarkers[J]. FRONTIERS IN GENETICS,2019,10(3):1-13. |
APA | Feng, X .,Li, JL .,Li, H .,Chen, H .,Li, F .,...&Zhou, FF .(2019).Age Is Important for the Early-Stage Detection of Breast Cancer on Both Transcriptomic and Methylomic Biomarkers.FRONTIERS IN GENETICS,10(3),1-13. |
MLA | Feng, X ,et al."Age Is Important for the Early-Stage Detection of Breast Cancer on Both Transcriptomic and Methylomic Biomarkers".FRONTIERS IN GENETICS 10.3(2019):1-13. |
入库方式: OAI收割
来源:新疆理化技术研究所
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