N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice
文献类型：期刊论文
| 作者 | Zheng, Junping1,2,3,4; Yuan, Xubing2,3,4; Zhang, Chen3,4; Jia, Peiyuan3,4; Jiao, Siming3,4; Zhao, Xiaoming1; Yin, Heng1; Du, Yuguang3,4; Liu, Hongtao3,4,5 |
| 刊名 | JOURNAL OF DIABETES
 |
| 出版日期 | 2019 |
| 卷号 | 11期号:1页码:32-45 |
| ISSN号 | 1753-0393 |
| 关键词 | Akkermansia gut microbiota lipopolysaccharide metabolic syndrome N-acetylcysteine |
| DOI | 10.1111/1753-0407.12795 |
| 英文摘要 | Background: N-Acetylcysteine (NAC), an antioxidative reagent for clinical diseases, shows potential in the treatment of diabetes and other metabolic diseases. However, it is unknown how NAC modulates the gut microbiota of mice with metabolic syndrome. The aim of the present study was to demonstrate the preventive effect of NAC on intestinal dysbiosis and glucose metabolic disorder. Methods: Mice (C57BL/6J strain) were fed either a normal chow diet (NCD), NCD plus NAC, a high-fat diet (HFD), or HFD plus NAC for 5 months, after which glucose levels, circulating endotoxins and key metabolism-related proteins were determined. Fecal samples were analyzed by 16S rRNA sequencing. A novel analysis was performed to predict functional changes in gut microbiota. In addition, Spearman's correlation analysis was performed between metabolic biomarkers and bacterial abundance. Results: Treatment with NAC significantly reversed the glucose intolerance, fasting glucose concentrations, and gains in body weight and plasma endotoxin in HFD-fed mice. Further, NAC upregulated occludin and mucin glycoprotein levels in the proximal colon of HFD-treated mice. Noticeably, NAC promoted the growth of beneficial bacteria (i.e. Akkermansia, Bifidobacterium, Lactobacillus and Allobaculum) and decreased populations of diabetes-related genera, including Desulfovibrio and Blautia. In addition, NAC may affect the metabolic pathways of intestinal bacteria, including lipopolysaccharide biosynthesis, oxidative stress, and bacterial motility. Finally, the modified gut microbiota was closely associated with the metabolic changes in NAC-treated HFD-fed mice. Conclusions: N-Acetylcysteine may be a potential drug to prevent glucose metabolic disturbances by reshaping the structure of the gut microbiota. |
| WOS关键词 | MOLECULAR-MECHANISM ; INSULIN-RESISTANCE ; BIOFILM FORMATION ; ACETYL-CYSTEINE ; MICROBIOTA ; OBESITY ; INFLAMMATION ; ASSOCIATION ; BENEFITS ; GROWTH |
| 资助项目 | National Natural Science Foundation of China[31570801] ; National Natural Science Foundation of China[31500747] ; National Natural Science Foundation of China[31672077] ; National Programs for High Technology Research and Development (863 Programs)[2014AA093604] ; CAS Youth Innovation Promotion Association[2015144] |
| WOS研究方向 | Endocrinology & Metabolism |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000451868200006 |
| 资助机构 | National Natural Science Foundation of China ; National Programs for High Technology Research and Development (863 Programs) ; CAS Youth Innovation Promotion Association |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/27552]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Liu, Hongtao |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing, Peoples R China 5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Junping,Yuan, Xubing,Zhang, Chen,et al. N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice[J]. JOURNAL OF DIABETES,2019,11(1):32-45. |
| APA | Zheng, Junping.,Yuan, Xubing.,Zhang, Chen.,Jia, Peiyuan.,Jiao, Siming.,...&Liu, Hongtao.(2019).N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice.JOURNAL OF DIABETES,11(1),32-45. |
| MLA | Zheng, Junping,et al."N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice".JOURNAL OF DIABETES 11.1(2019):32-45. |
入库方式： OAI收割
来源：过程工程研究所
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