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Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement

文献类型：期刊论文

作者Zhou, Ruyi1,2; Wang, Huamei1,2; Yang, Yufei1,2; Zhang, Chenyang1,2; Dong, Xinghua1,2; Du, Jiangfeng4; Yan, Liang1,2; Zhang, Guangjin3; Gu, Zhanjun1,2; Zhao, Yuliang1,2
刊名BIOMATERIALS
出版日期2019
卷号189页码:11-22
关键词Polyoxometalates Radiocatalytic sensitizer Glutathione depletion Reactive oxygen species generation Tumor microenvironment-manipulation
ISSN号0142-9612
DOI10.1016/j.biomaterials.2018.10.016
英文摘要Radioresistance resulted from the intrinsic features of tumors often gives rise to unsatisfied therapeutic outcome. In particular, the tumor microenvironment (TME) with abundant antioxidants, elevated hydrogen peroxide (H2O2) and hypoxia has been believed as a tremendous obstacle for radiotherapy. Therefore, developing an effective radiosensitizer in response to both X-ray and the TME is highly imperative but remains a challenge so far. Here, we for the first time explore bismuth heteropolytungstate (BiP5W30) nanoclusters as radiosensitizers for the TME-manipulated enhancement of radiotherapy. On the one hand, BiP5W30 nanoclusters can increase radiation dose deposition within tumors by high-Z elements like Bi and W. On the other hand, in virtue of the unique electron structure and multi-electron property, they have the capability of depleting glutathione (GSH) via redox reaction and catalyzing the decomposition of H2O2 to HO center dot to enhance ROS generation upon X-ray radiation. Moreover, reduced graphene oxide (rGO) coupled with BiP5W30 can further improve radiocatalytic activity through promoting electron-hole separation. Simultaneously, due to the considerable near-infrared absorption of rGO, photothermal therapy can overcome the tumor hypoxia microenvironment and thus synergize with radiotherapy. In addition to providing a promising radiosensitizer, this finding is expected to extend the application of polyoxometalates used in the biomedical field.
WOS关键词PHOTODYNAMIC THERAPY ; OXIDATIVE STRESS ; GRAPHENE OXIDE ; POLYOXOMETALATE ; NANOPARTICLES ; SEMICONDUCTOR ; RELEASE ; RADIOSENSITIZATION ; DEGRADATION ; GLUTATHIONE
资助项目National Basic Research Program of China[2016YFA0201600] ; National Basic Research Program of China[2015CB932104] ; National Natural Science Foundation of China[51822207] ; National Natural Science Foundation of China[51772292] ; National Natural Science Foundation of China[31700866] ; National Natural Science Foundation of China[31571015] ; National Natural Science Foundation of China[11621505] ; National Natural Science Foundation of China[11435002] ; National Natural Science Foundation of China[21320102003] ; Youth Innovation Promotion Association CAS[2013007] ; Chinese Academy of Sciences Key Research Program of Frontier Sciences[QYZDJ-SSW-SLH022]
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:000452569300002
出版者ELSEVIER SCI LTD
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Chinese Academy of Sciences Key Research Program of Frontier Sciences
源URL[http://ir.ipe.ac.cn/handle/122111/27564]  
专题中国科学院过程工程研究所
通讯作者Yan, Liang; Zhang, Guangjin; Gu, Zhanjun
作者单位1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
2.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
4.Shanxi Med Univ, Hosp 1, Dept Med Imaging, Taiyuan 030001, Shanxi, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Ruyi,Wang, Huamei,Yang, Yufei,et al. Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement[J]. BIOMATERIALS,2019,189:11-22.
APA Zhou, Ruyi.,Wang, Huamei.,Yang, Yufei.,Zhang, Chenyang.,Dong, Xinghua.,...&Zhao, Yuliang.(2019).Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement.BIOMATERIALS,189,11-22.
MLA Zhou, Ruyi,et al."Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement".BIOMATERIALS 189(2019):11-22.

入库方式： OAI收割

来源：过程工程研究所

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