Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice
文献类型：期刊论文
| 作者 | Yuan, Xubing1,2,3; Zheng, Junping1,2,3; Ren, Lishi1,2; Jiao, Siming1,2; Feng, Cui1,2; Du, Yuguang1,2; Liu, Hongtao1,2 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2019-02-15 |
| 卷号 | 206页码:403-411 |
| ISSN号 | 0144-8617 |
| 关键词 | Enteromorpha prolifera oligomers Antioxidation Diabetes mellitus Inflammation Apoptosis |
| DOI | 10.1016/j.carbpol.2018.11.019 |
| 英文摘要 | The polysaccharides of Enteromorpha prolifera (PEP) displayed various bioactivities such as anti-viral, anti-inflammatory and immune-regulative effects. However, no studies were performed on the biological effect of Enteromorpha prolifera oligomers (EPO). In this study, we prepared EPO and evaluated their anti-diabetic effect By enzymatic degradation, EPO were produced from PEP, and the average molecular weight was identified to be 44.1 kDa by Gel Permeation Chromatography (GPC) analysis. The major monosaccharide units of EPO were measured to be rhamnose, glucuronic acid, glucose, xylose and galactose by capillary electrophoresis assay. Based on the in vitro studies, EPO presented potent reducing power and antioxidant effect such as the scavenging of 1, 1-dipheny1-2-picrylhydrazyl (DPPH), superoxide and NO radicals. The in vivo studies show that EPO relieved the symptoms of polydipsia, polyphagia, emaciation and hyperglycemia in streptozotocin (STZ)-induced diabetic mice to a certain extent Further, by using the quantitative real-time PCR (qPCR) assay and immuno-fluorescence staining, EPO was proved to promote the insulin secretion by reducing pancreatic inflammation and apoptosis in diabetic mice. In summary, our results indicate that the mitigation of EPO on pancreatic damage might be an effective way to ameliorate the diabetes mellitus. |
| WOS关键词 | IN-VITRO ANTIOXIDANT ; SULFATED POLYSACCHARIDES ; DEGRADED POLYSACCHARIDES ; PURIFICATION ; INFLAMMATION ; EXTRACTION ; LINZA |
| 资助项目 | National Natural Science Foundation Of China[31570801] ; National Natural Science Foundation Of China[31500747] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000452982700046 |
| 资助机构 | National Natural Science Foundation Of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/27613]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Du, Yuguang; Liu, Hongtao |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Key Lab Biopharmaceut Prod & Formulat Engn, PLA, Inst Proc Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Xubing,Zheng, Junping,Ren, Lishi,et al. Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice[J]. CARBOHYDRATE POLYMERS,2019,206:403-411. |
| APA | Yuan, Xubing.,Zheng, Junping.,Ren, Lishi.,Jiao, Siming.,Feng, Cui.,...&Liu, Hongtao.(2019).Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice.CARBOHYDRATE POLYMERS,206,403-411. |
| MLA | Yuan, Xubing,et al."Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice".CARBOHYDRATE POLYMERS 206(2019):403-411. |
入库方式： OAI收割
来源：过程工程研究所
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