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Direct conversion of shrimp shells to O-acylated chitin with antibacterial and anti-tumor effects by natural deep eutectic solvents

文献类型：期刊论文

作者Feng, Mi1,2; Lu, Xingmei1,2; Zhang, Jie2; Li, Yi3; Shi, Chunyan2; Lu, Lingling3; Zhang, Suojiang1,2
刊名GREEN CHEMISTRY
出版日期2019-01-07
卷号21期号:1页码:87-98
ISSN号1463-9262
DOI10.1039/c8gc02506a
英文摘要To obtain O-acylated chitin from shrimp shells directly, the used solvent should have multiple functions to remove calcium carbonate, protein, and acylated chitin. Herein, we use the acidic natural deep eutectic solvents (NADESs) with the ability to release H+ and various hydrogen bonding sites to achieve the above goal. The involved NADESs with three abilities of decalcification, deproteinization and acylation replaced acids, alkalis, catalysts, and acylation reagents in the conventional method. The experimental results revealed that the components of the NADESs, experiment temperature and time played key roles in the purity and degree of substitution (DS) of O-acylated chitin. Meanwhile, the ratio of shrimp shells to NADESs and a small amount of water had little effect on the preparation of O-acylated chitin. With the optimal NADES (choline chloride/dl-malic acid 1:2, ChCl 1-dl Mal 2) treatment under the optimal conditions, the purity of O-malate chitin reached 98.6% with a DS of 0.46, exhibiting antibacterial and anti-tumor effects. The experimental results showed that the removal of calcium carbonate and protein and acylation of chitin were carried out simultaneously. Mechanistic exploration using spectroscopy and experiments confirmed that H+ release from ChCl 1-dl Mal 2 was the main reason for the removal of calcium carbonate and initiation acylation reaction. The protein was degraded to amino acids because of the acidity of ChCl 1-dl Mal 2 and dissolved in the NADES due to hydrogen bonding formation with ChCl 1-dl Mal 2.
WOS关键词CHOLINE CHLORIDE ; AQUEOUS-SOLUTION ; LOBSTER SHELLS ; IONIC LIQUIDS ; HIGH-PURITY ; CHITOSAN ; EXTRACTION ; WASTE ; DERIVATIVES ; WATER
资助项目National Basic Research Program of China (973 Program)[2015CB251401] ; Natural Scientific Fund of China[21476234] ; Natural Scientific Fund of China[21506231] ; National CAS/SAFEA International Partnership Program for Creative Research Teams[20140491518] ; Key Research Program of Frontier Sciences CAS[QYZDY-SSW-JSC011]
WOS研究方向Chemistry ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:000454943500008
出版者ROYAL SOC CHEMISTRY
资助机构National Basic Research Program of China (973 Program) ; Natural Scientific Fund of China ; National CAS/SAFEA International Partnership Program for Creative Research Teams ; Key Research Program of Frontier Sciences CAS
源URL[http://ir.ipe.ac.cn/handle/122111/27698]  
专题中国科学院过程工程研究所
通讯作者Lu, Xingmei; Zhang, Suojiang
作者单位1.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, State Key Lab Multiphase Complex Syst, CAS Key Lab Green Proc & Engn,Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem & Engn, Beijing 100049, Peoples R China
3.Capital Med Univ, Beijing Ctr Neural Regenerat & Repair, Key Lab Neurodegenerat Dis,Beijing Inst Brain Dis, Ctr Parkinsons Dis,Dept Neurobiol,Minist Educ, Beijing 100054, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Mi,Lu, Xingmei,Zhang, Jie,et al. Direct conversion of shrimp shells to O-acylated chitin with antibacterial and anti-tumor effects by natural deep eutectic solvents[J]. GREEN CHEMISTRY,2019,21(1):87-98.
APA Feng, Mi.,Lu, Xingmei.,Zhang, Jie.,Li, Yi.,Shi, Chunyan.,...&Zhang, Suojiang.(2019).Direct conversion of shrimp shells to O-acylated chitin with antibacterial and anti-tumor effects by natural deep eutectic solvents.GREEN CHEMISTRY,21(1),87-98.
MLA Feng, Mi,et al."Direct conversion of shrimp shells to O-acylated chitin with antibacterial and anti-tumor effects by natural deep eutectic solvents".GREEN CHEMISTRY 21.1(2019):87-98.

入库方式： OAI收割

来源：过程工程研究所

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