Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant
文献类型：期刊论文
| 作者 | Tong, Liping1; Liao, Qing1; Zhao, Yuetao1; Huang, Hao1; Gao, Ang1,2; Zhang, Wei3; Gao, Xiaoyong4; Wei, Wei4; Guan, Min1; Chu, Paul K.2 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 193页码:1-11 |
| ISSN号 | 0142-9612 |
| 关键词 | Tissue engineering Black phosphorus Bone regeneration Photothermal therapy |
| DOI | 10.1016/j.biomaterials.2018.12.008 |
| 英文摘要 | Mild heat stimulation can promote the restoration of bone defects but unfortunately, the delivery of exo-hyperthermy into human body is not efficient enough. In this study, mild heat-induced osteogenesis with high efficacy is demonstrated on an osteoimplant composed of black phosphorus nanosheets and poly(lactic-co-glycolic acid) (BPs@PLGA) with the participation of near-infrared (NIR) light irradiation. BPs@PLGA with only 0.2 wt% BPs show the highly-efficient NIR photothermal response even when being covered by a biological tissue as thick as 7 mm. In addition, this composite is completely biodegradable and the final degradation products are harmless H2O, CO2 and PO43- which can serve as necessary bone ingredient. The BPs@PLGA specimen mediated by low intensity and periodic NIR irradiation can effectively up-regulate the expressions of heat shock proteins and finally promote osteogenesis in vitro and in vivo. Boasting good biodegradability and NIR-mediated osteogenetic performances, the BPs@PLGA implant has great potential in orthopedic applications and this study provides new insights into the design and fabrication of new-style osteoimplants which can be remotely controlled. |
| WOS关键词 | BLACK PHOSPHORUS ; IN-VIVO ; GRAPHENE OXIDE ; HEAT-SHOCK ; SURFACE ; HSP47 ; OSTEOGENESIS ; HYPERTHERMIA ; STIMULATION ; DEGRADATION |
| 资助项目 | National Natural Science Foundation of China[51503220] ; Shenzhen Science and Technology Research Funding[JSGG20160229195900623] ; Shenzhen Science and Technology Research Funding[JCYJ20160429190215470] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2017416] ; Youth Talents of Guangdong Science and Technology Innovation[2015TQ010534] ; Leading Talents of Guangdong Province Program[00201520] ; Shenzhen Peacock Program[KQTD2016030111500545] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Hong Kong Research Grants Council (RGC) General Research Funds[CityU 11301215] ; Hong Kong Research Grants Council (RGC) General Research Funds[11205617] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000457665800001 |
| 资助机构 | National Natural Science Foundation of China ; Shenzhen Science and Technology Research Funding ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Talents of Guangdong Science and Technology Innovation ; Leading Talents of Guangdong Province Program ; Shenzhen Peacock Program ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Hong Kong Research Grants Council (RGC) General Research Funds |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/27870]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wang, Huaiyu |
| 作者单位 | 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Shenzhen 518055, Peoples R China 2.City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tong, Liping,Liao, Qing,Zhao, Yuetao,et al. Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant[J]. BIOMATERIALS,2019,193:1-11. |
| APA | Tong, Liping.,Liao, Qing.,Zhao, Yuetao.,Huang, Hao.,Gao, Ang.,...&Wang, Huaiyu.(2019).Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant.BIOMATERIALS,193,1-11. |
| MLA | Tong, Liping,et al."Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant".BIOMATERIALS 193(2019):1-11. |
入库方式： OAI收割
来源：过程工程研究所
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