Covalently Assembled Dipeptide Nanoparticles with Adjustable Fluorescence Emission for Multicolor Bioimaging
文献类型：期刊论文
| 作者 | Li, Shukun1; Liu, Yamei1; Xing, Ruirui1; Yan, Xuehai1,2 |
| 刊名 | CHEMBIOCHEM
 |
| 出版日期 | 2019-02-15 |
| 卷号 | 20期号:4页码:555-560 |
| 关键词 | fluorescence imaging agents nanoparticles peptides self-assembly |
| ISSN号 | 1439-4227 |
| DOI | 10.1002/cbic.201800434 |
| 英文摘要 | Peptide self-assembly, inspired by the naturally occurring fabrication principle, remains the most attractive in constructing fluorescent nanoagents towards bioimaging. However, the noncovalent interactions that drive peptide self-assembly are usually susceptible to the complex physiological environment; thus leading to disassembly and dysfunction of fluorescent nanoagents. Herein, a covalently crosslinked assembly strategy for fabrication of stable peptide-based nanoparticles with adjustable emission is introduced. In the process of cationic diphenylalanine peptide (H-Phe-Phe-NH2 center dot HCl) self-assembly, glutaraldehyde is used as a crosslinker and the resulting product of the Schiff base reaction can be fluorescent. More importantly, the emission wavelength can be readily tuned by controlling the covalent reaction time. It has been demonstrated that the nanoparticles are stable, even after intracellular uptake, and can be used for sustainable multicolor fluorescent imaging. The strategy with integrating peptide self-assembly and covalent crosslinking could be promising for the design and engineering of functional fluorescent nanoparticles with robust physiological stability and adjustable emission towards improved bioimaging applications. |
| WOS关键词 | CONJUGATED POLYMER NANOPARTICLES ; SEMICONDUCTING POLYMER ; CONSTRUCTION ; NANOCARRIERS ; DELIVERY ; DESIGN ; PROBES ; DOTS ; TIME |
| 资助项目 | National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21473208] ; National Natural Science Foundation of China[201773248] ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of the Frontier Sciences of the Chinese Academy of Sciences[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000458825800016 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of the Frontier Sciences of the Chinese Academy of Sciences ; CAS President's International Fellowship Initiative |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/28029]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yan, Xuehai |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North Second St, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shukun,Liu, Yamei,Xing, Ruirui,et al. Covalently Assembled Dipeptide Nanoparticles with Adjustable Fluorescence Emission for Multicolor Bioimaging[J]. CHEMBIOCHEM,2019,20(4):555-560. |
| APA | Li, Shukun,Liu, Yamei,Xing, Ruirui,&Yan, Xuehai.(2019).Covalently Assembled Dipeptide Nanoparticles with Adjustable Fluorescence Emission for Multicolor Bioimaging.CHEMBIOCHEM,20(4),555-560. |
| MLA | Li, Shukun,et al."Covalently Assembled Dipeptide Nanoparticles with Adjustable Fluorescence Emission for Multicolor Bioimaging".CHEMBIOCHEM 20.4(2019):555-560. |
入库方式： OAI收割
来源：过程工程研究所
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