Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers
文献类型：期刊论文
| 作者 | Wang, Quan1; Zhang, Ruirui2,3; You, Guoxing1; Hu, Jilin1; Li, Penglong1; Wang, Ying1; Zhang, Jun1; Wu, Yan2; Zhao, Lian1; Zhou, Hong1 |
| 刊名 | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 46页码:484-492 |
| 关键词 | Polydopamine haemoglobin surface modification oxygen carriers oxidative toxicity |
| ISSN号 | 2169-1401 |
| DOI | 10.1080/21691401.2018.1459636 |
| 英文摘要 | Oxidative toxicity has impeded the development of haemoglobin-based oxygen carriers (HBOCs) by causing methaemoglobin (MetHb) formation and inducing oxidative stress. In our previous work, polydopamine-coated haemoglobin (Hb-PDA) nanoparticles have been designed and synthesized with the capacity to reduce oxidative toxicity. In this investigation, the mass ratio of dopamine (DA) to haemoglobin (Hb) and the pH value are found to be the primary factors that influence preparation of Hb-PDA nanoparticles. X-ray photoelectron spectroscopy showed that the catechol groups of DA play a crucial role in the modification of Hb surface. Hb-PDA nanoparticles were found to exhibit oxidative protection from hydrogen peroxide (H2O2) and the change of mitochondrial membrane potential showed that the Hb-PDA nanoparticles reduced H2O2-induced apoptosis. It is demonstrated that modification of PDA could maintain the oxygen-release capacity of Hb. These findings confirm that Hb-PDA nanoparticles possess restrained oxidative toxicity and preserve oxygen-release capacity. |
| WOS关键词 | OXIDE SURFACES ; NANOPARTICLES ; BINDING ; BLOOD ; PERFORMANCE |
| 资助项目 | National Natural Science Foundation of China[81700181] ; National Natural Science Foundation of China[81600148] ; National Natural Science Foundation of China[21705151] ; Beijing Natural Science Foundation[2174085] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000459181400047 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | National Natural Science Foundation of China ; Beijing Natural Science Foundation |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/28035]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wu, Yan; Zhao, Lian; Zhou, Hong |
| 作者单位 | 1.Acad Mil Med Sci, Inst Hlth Serv & Transfus Med, Beijing Key Lab Blood Safety & Supply Technol, Beijing, Peoples R China 2.Natl Ctr Nanosci & Technol, Beijing, Peoples R China 3.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Quan,Zhang, Ruirui,You, Guoxing,et al. Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2018,46:484-492. |
| APA | Wang, Quan.,Zhang, Ruirui.,You, Guoxing.,Hu, Jilin.,Li, Penglong.,...&Zhou, Hong.(2018).Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,46,484-492. |
| MLA | Wang, Quan,et al."Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46(2018):484-492. |
入库方式： OAI收割
来源：过程工程研究所
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