中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 武汉植物园
  3. 中国科学院武汉植物园
Yersinia pseudotuberculosis Exploits CD209 Receptors for Promoting Host Dissemination and Infection

文献类型：期刊论文

作者Chen, Tie12; Skurnik, Mikael2; Klena, John D.1; Fu, Yang-Xin3; Peng, Hua4; Yang, Rui-Fu5; Jing, Huai-Qi6; Wang, Xin6; Kan, Biao6; Xia, Lian-Xu6
刊名INFECTION AND IMMUNITY
出版日期2019
卷号87期号:1页码:16
ISSN号0019-9567
关键词Yersinia pseudotuberculosis dendritic cells DCs DC-SIGN CD209a SIGN-R1 CD209b lipopolysaccharide core LPS core dissemination
DOI10.1128/IAI.00654-18
英文摘要Yersinia pseudotuberculosis is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals. Although the molecular mechanisms for dissemination and infection are unclear, many Gram-negative enteropathogens presumably invade the small intestine via Peyer's patches to initiate dissemination. In this study, we demonstrate that Y. pseudotuberculosis utilizes its lipopolysaccharide (LPS) core to interact with CD209 receptors, leading to invasion of human dendritic cells (DCs) and murine macrophages. These Y. pseudotuberculosis CD209 interactions result in bacterial dissemination to MLNs, spleens, and livers of both wild-type and Peyer's patch-deficient mice. The blocking of the Y. pseudotuberculosis CD209 interactions by expression of 0-antigen and with oligosaccharides reduces infectivity. Based on the well-documented studies in which HIV-CD209 interaction leads to viral dissemination, we therefore propose an infection route for Y. pseudotuberculosis where this pathogen, after penetrating the intestinal mucosal membrane, hijacks the Y. pseudotuberculosis CD209 interaction antigen-presenting cells to reach their target destinations, MLNs, spleens, and livers.
资助项目PHS[R01AI 47736] ; National Natural Science Foundation of China (NSFC)[81271780] ; National Natural Science Foundation of China (NSFC)[81471915] ; Tongji Hospital, Tongji Medical College ; National Research Foundation of Korea[NRF-2013R1A1A2058427] ; National Research Foundation of Korea[NRF-2014R1A4A1008625] ; Yonsei University College of Medicine[6-2014-0062] ; Rockefeller University ; Tongji Hospital, HUST
WOS研究方向Immunology ; Infectious Diseases
语种英语
出版者AMER SOC MICROBIOLOGY
WOS记录号WOS:000453781400015
源URL[http://202.127.146.157/handle/2RYDP1HH/6310]  
专题中国科学院武汉植物园
通讯作者Chen, Tie; Skurnik, Mikael
作者单位1.Ctr Dis Control & Prevent, Atlanta, GA USA
2.Univ Helsinki, Dept Bacteriol & Immunol, Helsinki, Finland
3.Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX USA
4.Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing, Peoples R China
5.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China
6.Natl Inst Communicable Dis Control & Prevent, Dept Diarrheal Dis, Beijing, Peoples R China
7.Chinese Acad Sci, Wuhan Inst Virol, Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China
8.Univ Illinois, Coll Med Rockford, Dept Biomed Sci, Rockford, IL USA
9.Univ Zambia Univ Coll London Med Sch Zambia, Dept Paediat & Child Hlth, Lusaka, Zambia
10.Shihezi Univ, Sch Med, Dept Pathogen Biol & Immunol, Shihezi, Xinjiang, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Tie,Skurnik, Mikael,Klena, John D.,et al. Yersinia pseudotuberculosis Exploits CD209 Receptors for Promoting Host Dissemination and Infection[J]. INFECTION AND IMMUNITY,2019,87(1):16.
APA Chen, Tie.,Skurnik, Mikael.,Klena, John D..,Fu, Yang-Xin.,Peng, Hua.,...&He, Ying-Xia.(2019).Yersinia pseudotuberculosis Exploits CD209 Receptors for Promoting Host Dissemination and Infection.INFECTION AND IMMUNITY,87(1),16.
MLA Chen, Tie,et al."Yersinia pseudotuberculosis Exploits CD209 Receptors for Promoting Host Dissemination and Infection".INFECTION AND IMMUNITY 87.1(2019):16.

入库方式： OAI收割

来源：武汉植物园

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。