Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016
文献类型：期刊论文
| 作者 | Bi, Yuhai3,9; Shi, Weifeng10; Liu, William J.8; Gao, George F.1,3,9; Liu, Wenjun9; Liu, Yingxia3; Yu, Hongjie1; Feng, Luzhao1; Wang, Qianli8; Wong, Gary2,3 |
| 刊名 | TRANSBOUNDARY AND EMERGING DISEASES
 |
| 出版日期 | 2019 |
| 卷号 | 66期号:1页码:592-598 |
| 关键词 | evolution H6 subtype low pathogenic avian influenza molecular characterization reassortment |
| ISSN号 | 1865-1674 |
| DOI | 10.1111/tbed.13037 |
| 英文摘要 | H6 subtype avian influenza virus (AIV) was prevalent in poultry and could sporadically infect humans. Here, a total of 196 novel H6 AIVs isolated from poultry in eight provinces of China from 2014 to 2016 were phylogenetically characterized. Our analysis revealed that they could be divided into two clades in the Asian H6 HA lineage, A/wild duck/Shantou/2853/2003(H6N2) (ST2853-like) (85.7%) and A/duck/Shantou/339/2000(H6N2) (ST339-like) (14.3%), in which ST2853-like strains predominate. These novel strains belonged to the H6N6 (n = 165, 84.2%), H6N2 (n = 30, 15.3%), and H6N3 (n = 1, 0.51%) subtypes, which could be classified into 36 genotypes including 12 novel genotypes described in this study. In particular, several strains possessed the V190 and S228 mutations in HA (H3 numbering), which is critical for human receptor binding and identical to the human-derived strain A/Taiwan/2/2013(H6N1). Furthermore, 10.3% of the H6N6 isolates possessed the N6- increment 11b (59-69) deletion. In summary, we describe phylogenetic and molecular characterizations of H6 AIVs in southern China and highlight the constant prevalence of H6 AIVs in poultry as well as adaptation to mammalian hosts. |
| 资助项目 | National Key Research and Development Project of China[2016YFE0205800] ; National Key Science and Technology Projects of China[2017ZX10104001-006] ; National Key Science and Technology Projects of China[2016ZX10004222] ; Sanming Project of Medicine in Shenzhen[SZSM201412003] ; Emergency Technology Research Issue on Prevention and Control for Human Infection with A (H7N9) Avian Influenza Virus[10600100000015001206] ; Taishan Scholars program of Shandong Province[ts201511056] ; National Natural Science Fund for Outstanding Young Scholars[31822055] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2017122] |
| WOS研究方向 | Infectious Diseases ; Veterinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000456344900064 |
| 出版者 | WILEY |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/6483]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Bi, Yuhai; Shi, Weifeng |
| 作者单位 | 1.Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China 2.Univ Laval, Dept Microbiol Infectiol & Immunol, Quebec City, PQ, Canada 3.Southern Univ Sci & Technol, Shenzhen Key Lab Pathogen & Immun, Shenzhen Peoples Hosp 3, Hosp Affiliated 2,State Key Discipline Infect Dis, Shenzhen, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China 5.Henan Prov Ctr Dis Control & Prevent, Zhengzhou, Henan, Peoples R China 6.Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China 7.Jiangxi Prov Ctr Dis Control & Prevent, Nanchang, Jiangxi, Peoples R China 8.Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China 9.Chinese Acad Sci, Inst Microbiol, Ctr Influenza Res & Early Warning CASCIRE, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 10.Taishan Med Coll, Key Lab Etiol & Epidemiol Emerging Infect Dis Sha, Tai An, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bi, Yuhai,Shi, Weifeng,Liu, William J.,et al. Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016[J]. TRANSBOUNDARY AND EMERGING DISEASES,2019,66(1):592-598. |
| APA | Bi, Yuhai.,Shi, Weifeng.,Liu, William J..,Gao, George F..,Liu, Wenjun.,...&Li, Juan.(2019).Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016.TRANSBOUNDARY AND EMERGING DISEASES,66(1),592-598. |
| MLA | Bi, Yuhai,et al."Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016".TRANSBOUNDARY AND EMERGING DISEASES 66.1(2019):592-598. |
入库方式： OAI收割
来源：武汉植物园
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