Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish
文献类型：期刊论文
| 作者 | Sun, Yuhua2; Dougan, Scott1; Munisha, Mumingjiang1; Zhang, Yanyong2; Chen, Ji2; Sun, Xiaoyun2 |
| 刊名 | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2018-09-28 |
| 卷号 | 6页码:14 |
| 关键词 | Mga Bmp signaling Zmynd11 Bs69 Bmpr1a ventral tailfin |
| ISSN号 | 2296-634X |
| DOI | 10.3389/fcell.2018.00126 |
| 英文摘要 | MAX giant associated protein (MGA) is a dual transcriptional factor containing both T-box and bHLHzip DNA binding domains. In vitro studies have shown that MGA functions as a transcriptional repressor or activator to regulate transcription of promotors containing either E-box or T-box binding sites. BS69 (ZMYND11), a multidomain-containing (i.e., PHD, BROMO, PWWP, and MYND) protein, has been shown to selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3), modulates RNA Polymerase II elongation, and functions as RNA splicing regulator. Mutations in MGA or BS69 have been linked to multiple cancers or neural developmental disorders. Here, by TALEN and CRISPR/Cas9-mediated loss of gene function assays, we show that zebrafish Mga and Bs69 are required to maintain proper Bmp signaling during early embryogenesis. We found that Mga protein localized in the cytoplasm modulates Bmpr1a activity by physical association with Zmynd11/Bs69. The Mynd domain of Bs69 specifically binds the kinase domain of Bmpr1a and interferes with its phosphorylation and activation of Smad1/5/8. Mga acts to antagonize Bs69 and facilitate the Bmp signaling pathway by disrupting the Bs69-Bmpr1a association. Functionally, Bmp signaling under control of Mga and Bs69 is required for properly specifying the ventral tailfin cell fate. |
| 资助项目 | National Key Research and Development Program[2016YFA0101100] ; National Natural Science Foundation of China[31671526] ; Hundred-Talent Program (CAS)[Y623041501] ; Hundred-Talent Program (IHB)[Y623041501] |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000455343400002 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/6524]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Sun, Yuhua; Dougan, Scott |
| 作者单位 | 1.Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yuhua,Dougan, Scott,Munisha, Mumingjiang,et al. Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2018,6:14. |
| APA | Sun, Yuhua,Dougan, Scott,Munisha, Mumingjiang,Zhang, Yanyong,Chen, Ji,&Sun, Xiaoyun.(2018).Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,6,14. |
| MLA | Sun, Yuhua,et al."Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 6(2018):14. |
入库方式： OAI收割
来源：武汉植物园
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