Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus
文献类型：期刊论文
| 作者 | Zheng, Aihua1,6,7; Yuan, Fei2; Zou, Zhen6,7; Chandran, Kartik5; Deng, Fei3,6; Zhang, Xing6; Xia, Dequan4; Wu, Cuiping4; Jangra, Rohit K.5; Qi, Yue7 |
| 刊名 | NPJ VACCINES
 |
| 出版日期 | 2019-01-25 |
| 卷号 | 4页码:11 |
| ISSN号 | 2059-0105 |
| DOI | 10.1038/s41541-018-0096-y |
| 英文摘要 | Severe fever with thrombocytopenia virus (SFTSV) is an emerging tick-borne phlebovirus that causes lethal human disease, for which there are no licensed antiviral vaccines or therapies. Herein, we developed a live attenuated recombinant vesicular stomatitis virus (rVSV)-based vaccine candidate expressing the SFTSV Gn/Gc glycoproteins (rVSV-SFTSV/AH12-GP). High titers of cross-protective, broadly neutralizing antibodies were elicited by a single dose of rVSV-SFTSV/AH12-GP in both immunocompetent and immunocompromised mice against multiple strains of SFTSV and the related but distinct phlebovirus Heartland virus (HRTV). Remarkably, complete protection against lethal challenge with SFTSV was conferred in young and old immunocompromised mice irrespective of any pre-existing vector-specific immunity. Collectively, these results suggest that a rVSV vector expressing SFTSV glycoproteins is a promising candidate vaccine against two emerging phleboviruses associated with severe human diseases. |
| 资助项目 | National Key Plan for Scientific Research and Development of China[2016YFD0500303] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB11030800] ; Open Research Fund Program of State Key Laboratory of Integrated Pest Management[IPM1511] ; Open Research Fund Program of State Key Laboratory of Integrated Pest Management[IPM1603] |
| WOS研究方向 | Immunology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000457026700001 |
| 出版者 | SPRINGERNATURE |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/6552]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Zheng, Aihua; Yuan, Fei |
| 作者单位 | 1.Henan Normal Univ, Coll Life Sci, Xinxiang, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China 4.Yidu Cent Hosp Weifang, Dept Infect Dis, Weifang, Peoples R China 5.Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Aihua,Yuan, Fei,Zou, Zhen,et al. Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus[J]. NPJ VACCINES,2019,4:11. |
| APA | Zheng, Aihua.,Yuan, Fei.,Zou, Zhen.,Chandran, Kartik.,Deng, Fei.,...&Dong, Fangfang.(2019).Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus.NPJ VACCINES,4,11. |
| MLA | Zheng, Aihua,et al."Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus".NPJ VACCINES 4(2019):11. |
入库方式： OAI收割
来源：武汉植物园
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