A gene regulatory network anchored by LIM homeobox 1 for embryonic head development
文献类型:期刊论文
作者 | Sibbritt, Tennille1,2; Ip, Chi K.1; Khoo, Poh-Lynn1; Wilkie, Emilie1,3; Jones, Vanessa1; Sun, Jane Q. J.1; Shen, Joanne X.1; Osteil, Pierre1,2; Tam, Patrick P. L.1,2; Fossat, Nicolas1,2 |
刊名 | GENESIS |
出版日期 | 2018 |
卷号 | 56期号:9页码:- |
ISSN号 | 1526-954X |
关键词 | Primitive Streak Formation Zinc-finger Protein Mouse Embryo Visceral Endoderm Transcription Factor Anterior Mesendoderm Cranial Mesoderm Cell Fates Body Plan Gastrulation |
DOI | 10.1002/dvg.23246 |
文献子类 | Article |
英文摘要 | Development of the embryonic head is driven by the activity of gene regulatory networks of transcription factors. LHX1 is a homeobox transcription factor that plays an essential role in the formation of the embryonic head. The loss of LHX1 function results in anterior truncation of the embryo caused by the disruption of morphogenetic movement of tissue precursors and the dysregulation of WNT signaling activity. Profiling the gene expression pattern in the Lhx1 mutant embryo revealed that tissues in anterior germ layers acquire posterior tissue characteristics, suggesting LHX1 activity is required for the allocation and patterning of head precursor tissues. Here, we used LHX1 as an entry point to delineate its transcriptional targets and interactors and construct a LHX1-anchored gene regulatory network. Using a gain-of-function approach, we identified genes that immediately respond to Lhx1 activation. Meta-analysis of the datasets of LHX1-responsive genes and genes expressed in the anterior tissues of mouse embryos at head-fold stage, in conjunction with published Xenopus embryonic LHX1 (Xlim1) ChIP-seq data, has pinpointed the putative transcriptional targets of LHX1 and an array of genetic determinants functioning together in the formation of the mouse embryonic head. |
电子版国际标准刊号 | 1526-968X |
WOS研究方向 | Developmental Biology ; Genetics & Heredity |
语种 | 英语 |
WOS记录号 | WOS:000445606900003 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3368] |
专题 | 生化所2018年发文 |
通讯作者 | Sibbritt, Tennille |
作者单位 | 1.Univ Sydney, Childrens Med Res Inst, Embryol Unit, Sydney, NSW, Australia; 2.Univ Sydney, Sch Med Sci, Fac Med & Hlth, Sydney, NSW, Australia; 3.Univ Sydney, Childrens Med Res Inst, Bioinformat Unit, Sydney, NSW, Australia; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Partner Inst Computat Biol,Collaborat, Key Lab Computat Biol,CAS Ctr Excellence Mol Cell, Shanghai, Peoples R China; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 7.Monash Univ, Australian Regenerat Med Inst, Melbourne, Vic, Australia |
推荐引用方式 GB/T 7714 | Sibbritt, Tennille,Ip, Chi K.,Khoo, Poh-Lynn,et al. A gene regulatory network anchored by LIM homeobox 1 for embryonic head development[J]. GENESIS,2018,56(9):-. |
APA | Sibbritt, Tennille.,Ip, Chi K..,Khoo, Poh-Lynn.,Wilkie, Emilie.,Jones, Vanessa.,...&Ramialison, Mirana.(2018).A gene regulatory network anchored by LIM homeobox 1 for embryonic head development.GENESIS,56(9),-. |
MLA | Sibbritt, Tennille,et al."A gene regulatory network anchored by LIM homeobox 1 for embryonic head development".GENESIS 56.9(2018):-. |
入库方式: OAI收割
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