Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
文献类型:期刊论文
作者 | Zhang, Yajuan1,2; Wang, Xiongjun1,2; Cai, Guoqing1,2; Liu, Ruilong1,2; Gao, Hong1,2; Liang, Ji1,2; Yang, Weiwei1,2; Yu, Guanzhen3; Chu, Huiying4; Li, Guohui4 |
刊名 | MOLECULAR CELL |
出版日期 | 2018 |
卷号 | 71期号:2页码:201-+ |
ISSN号 | 1097-2765 |
关键词 | Tumor-associated Macrophages Cancer-cell Metabolism Blood-brain-barrier Phosphoglycerate Kinase Human Glioblastoma Microenvironment Progression Expression Pkm2 Pdk1 |
DOI | 10.1016/j.molcel.2018.06.023 |
文献子类 | Article |
英文摘要 | Macrophages are a dominant leukocyte population in the tumor microenvironment and actively promote cancer progression. However, the molecular mechanism underlying the role of macrophages remains poorly understood. Here we show that polarized M2 macrophages enhance 3-phosphoinositide-dependent protein kinase 1 (PDPK1)-mediated phosphoglycerate kinase 1 (PGK1) threonine (T) 243 phosphorylation in tumor cells by secreting inter-leukin-6 (IL-6).This phosphorylation facilitates a PGK1-catalyzed reaction toward glycolysis by altering substrate affinity. Inhibition of PGK1 T243 phosphorylation or PDPK1 in tumor cells or neutralization of macrophage-derived IL-6 abrogates macrophage-promoted glycolysis, proliferation, and tumorigenesis. In addition, PGK1 T243 phosphorylation correlates with PDPK1 activation, IL-6 expression, and macrophage infiltration in human glioblastoma multiforme (GBM). Moreover, PGK1 T243 phosphorylation also correlates with malignance and prognosis of human GBM. Our findings demonstrate a novel mechanism of macrophage-promoted tumor growth by regulating tumor cell metabolism, implicating the therapeutic potential to disrupt the connection between macrophages and tumor cells by inhibiting PGK1 phosphorylation. |
电子版国际标准刊号 | 1097-4164 |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000439117700004 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3435] |
专题 | 生化所2018年发文 |
通讯作者 | Yang, Weiwei |
作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, Shanghai 200031, Peoples R China; 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai 200031, Peoples R China; 3.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Oncol, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Lab Mol Modeling & Design, Dalian 116023, Peoples R China; 5.Wenzhou Med Coll, Affiliated Hosp 1, Dept Radiat Oncol, Wenzhou 325000, Zhejiang, Peoples R China; 6.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Neurosurg, Shanghai 200092, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Yajuan,Wang, Xiongjun,Cai, Guoqing,et al. Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis[J]. MOLECULAR CELL,2018,71(2):201-+. |
APA | Zhang, Yajuan.,Wang, Xiongjun.,Cai, Guoqing.,Liu, Ruilong.,Gao, Hong.,...&Tao, Bangbao.(2018).Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis.MOLECULAR CELL,71(2),201-+. |
MLA | Zhang, Yajuan,et al."Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis".MOLECULAR CELL 71.2(2018):201-+. |
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