Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning
文献类型:期刊论文
作者 | Cui, Guizhong1; Wang, Ran1; Qian, Yun1; Peng, Guangdun1; Jing, Naihe1,5![]() |
刊名 | DEVELOPMENT GROWTH & DIFFERENTIATION
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出版日期 | 2018 |
卷号 | 60期号:8页码:463-472 |
关键词 | Embryonic Stem-cells Factor Database Genome-wide Gene Expression Embryogenesis Pluripotency Commitment Allocation Fate |
ISSN号 | 0012-1592 |
DOI | 10.1111/dgd.12568 |
文献子类 | Article |
英文摘要 | Gastrulation is a key milestone in early mouse development when multipotent epiblast cells are allocated to progenitors of diverse tissue lineages that constitute the ensemble of building blocks of the body plan. The analysis of gene function revealed that the activity of transcription factors is likely to be the fundamental driving force underpinning the lineage specification and tissue patterning in the primary germ layers. The developmental-spatial transcriptome of the gastrulating embryo revealed the concerted and interactive activity of the gene regulatory network anchored by development-related transcription factors. The findings of the network structure offer novel insights into the regionalization of tissue fates and enable tracking of the progression of epiblast patterning, leading to the construction of molecularly annotated fate maps of epiblast during gastrulation. |
电子版国际标准刊号 | 1440-169X |
WOS研究方向 | Cell Biology ; Developmental Biology |
语种 | 英语 |
WOS记录号 | WOS:000449487200001 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3440] ![]() |
专题 | 生化所2018年发文 |
通讯作者 | Jing, Naihe |
作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai, Peoples R China; 2.Chinese Acad Sci, Collaborat Innovat Ctr Genet & Dev Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biol Sci,Key Lab Computat Biol,Max, Shanghai, Peoples R China; 3.Univ Sydney, Childrens Med Res Inst, Embryol Unit, Sydney, NSW, Australia; 4.Univ Sydney, Fac Med & Hlth, Sch Med Sci, Sydney, NSW, Australia; 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 6.Chinese Acad Sci, Guangzhou Inst Biomed, CAS Key Lab Regenerat Biol, Guangzhou, Guangdong, Peoples R China; 7.Chinese Acad Sci, Guangzhou Inst Hlth, CAS Key Lab Regenerat Biol, Guangzhou, Guangdong, Peoples R China; 8.Chinese Acad Sci, Guangzhou Inst Biomed, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou Regenerat Med & Hlth Guangdong Lab GRMH, Guangzhou, Guangdong, Peoples R China; 9.Chinese Acad Sci, Guangzhou Inst Hlth, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou Regenerat Med & Hlth Guangdong Lab GRMH, Guangzhou, Guangdong, Peoples R China |
推荐引用方式 GB/T 7714 | Cui, Guizhong,Wang, Ran,Qian, Yun,et al. Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning[J]. DEVELOPMENT GROWTH & DIFFERENTIATION,2018,60(8):463-472. |
APA | Cui, Guizhong.,Wang, Ran.,Qian, Yun.,Peng, Guangdun.,Jing, Naihe.,...&Peng, Guangdun.(2018).Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning.DEVELOPMENT GROWTH & DIFFERENTIATION,60(8),463-472. |
MLA | Cui, Guizhong,et al."Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning".DEVELOPMENT GROWTH & DIFFERENTIATION 60.8(2018):463-472. |
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