N-6-Methyladenosines Modulate A-to-I RNA Editing
文献类型:期刊论文
作者 | Xiang, Jian-Feng1,2; Yang, Qin1; Yang, Li1,3; Liu, Chu-Xiao2; Wu, Man2,3; Chen, Ling-Ling2,3 |
刊名 | MOLECULAR CELL |
出版日期 | 2018 |
卷号 | 69期号:1页码:126-+ |
ISSN号 | 1097-2765 |
关键词 | Throughput Sequencing Data Gene-expression Regulation Messenger-rna Landscape Cells Epitranscriptome Translation Methylation Networks Reveals |
DOI | 10.1016/j.molcel.2017.12.006 |
文献子类 | Article |
英文摘要 | N-6-methyladenosine (m(6)A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m(6)A-positive and m(6)A-negative RNA populations. Both the presence and extent of A-to-I sites in m(6)A-negative RNA transcripts suggest a negative correlation between m(6)A and A-to-I. Suppression of m(6)A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m(6)A modification increases the association of m(6)A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m(6)A-depleted transcripts. Collectively, the effect of m(6)A on A-to-I suggests a previously underappreciated interplay between two distinct and abundant RNA modifications, highlighting a complex epitranscriptomic landscape. |
电子版国际标准刊号 | 1097-4164 |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000419255100013 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3443] |
专题 | 生化所2018年发文 上海生化细胞研究所_上海生科院生化细胞研究所 |
通讯作者 | Yang, Li; Chen, Ling-Ling |
作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China |
推荐引用方式 GB/T 7714 | Xiang, Jian-Feng,Yang, Qin,Yang, Li,et al. N-6-Methyladenosines Modulate A-to-I RNA Editing[J]. MOLECULAR CELL,2018,69(1):126-+. |
APA | Xiang, Jian-Feng,Yang, Qin,Yang, Li,Liu, Chu-Xiao,Wu, Man,&Chen, Ling-Ling.(2018).N-6-Methyladenosines Modulate A-to-I RNA Editing.MOLECULAR CELL,69(1),126-+. |
MLA | Xiang, Jian-Feng,et al."N-6-Methyladenosines Modulate A-to-I RNA Editing".MOLECULAR CELL 69.1(2018):126-+. |
入库方式: OAI收割
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。