中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
N-6-Methyladenosines Modulate A-to-I RNA Editing

文献类型:期刊论文

作者Xiang, Jian-Feng1,2; Yang, Qin1; Yang, Li1,3; Liu, Chu-Xiao2; Wu, Man2,3; Chen, Ling-Ling2,3
刊名MOLECULAR CELL
出版日期2018
卷号69期号:1页码:126-+
ISSN号1097-2765
关键词Throughput Sequencing Data Gene-expression Regulation Messenger-rna Landscape Cells Epitranscriptome Translation Methylation Networks Reveals
DOI10.1016/j.molcel.2017.12.006
文献子类Article
英文摘要

N-6-methyladenosine (m(6)A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m(6)A-positive and m(6)A-negative RNA populations. Both the presence and extent of A-to-I sites in m(6)A-negative RNA transcripts suggest a negative correlation between m(6)A and A-to-I. Suppression of m(6)A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m(6)A modification increases the association of m(6)A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m(6)A-depleted transcripts. Collectively, the effect of m(6)A on A-to-I suggests a previously underappreciated interplay between two distinct and abundant RNA modifications, highlighting a complex epitranscriptomic landscape.

电子版国际标准刊号1097-4164
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
WOS记录号WOS:000419255100013
版本出版稿
源URL[http://202.127.25.143/handle/331003/3443]  
专题生化所2018年发文
上海生化细胞研究所_上海生科院生化细胞研究所
通讯作者Yang, Li; Chen, Ling-Ling
作者单位1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
3.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714
Xiang, Jian-Feng,Yang, Qin,Yang, Li,et al. N-6-Methyladenosines Modulate A-to-I RNA Editing[J]. MOLECULAR CELL,2018,69(1):126-+.
APA Xiang, Jian-Feng,Yang, Qin,Yang, Li,Liu, Chu-Xiao,Wu, Man,&Chen, Ling-Ling.(2018).N-6-Methyladenosines Modulate A-to-I RNA Editing.MOLECULAR CELL,69(1),126-+.
MLA Xiang, Jian-Feng,et al."N-6-Methyladenosines Modulate A-to-I RNA Editing".MOLECULAR CELL 69.1(2018):126-+.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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