Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking
文献类型:期刊论文
作者 | Jin, Guang-Zhi1; Cong, Wen-Ming1; Zhang, Yajuan2,3; Wang, Xiongjun2,3; Wu, Siyang2,3; Wang, Siyao2,3; Gao, Hong2,3; Yang, Weiwei2,3; Wu, Xueyuan4; Zhou, Weiping5 |
刊名 | PLOS BIOLOGY |
出版日期 | 2018 |
卷号 | 16期号:10页码:- |
ISSN号 | 1545-7885 |
关键词 | Forkhead Box J2 Cancer-cells Glycogen Tissue Foxj2 Metabolism Sorafenib Migration Growth Overexpression |
DOI | 10.1371/journal.pbio.2006483 |
文献子类 | Article |
英文摘要 | Glycogen metabolism commonly altered in cancer is just beginning to be understood. Phosphoglucomutase 1 (PGM1), the first enzyme in glycogenesis that catalyzes the reversible conversion between glucose 1-phosphate (G-1-P) and glucose 6-phosphate (G-6-P), participates in both the breakdown and synthesis of glycogen. Here, we show that PGM1 is downregulated in hepatocellular carcinoma (HCC), which is associated with the malignancy and poor prognosis of HCC. Decreased PGM1 expression obstructed glycogenesis pathway, which leads to the increased flow of glucose into glycolysis, thereby promoting tumor cell proliferation and HCC development. The loss of forkhead box protein J2 (FOXJ2), at least partly due to low genomic copy number in HCC, releases cellular nucleic acid-binding protein (CNBP), a nucleic acid chaperon, to bind to and promote G-quadruplex formation in PGM1 promoter and therefore decreases PGM1 expression. In addition, integrated analyses of PGM1 and FOXJ2 expression provide a better prediction for the malignance and prognosis of HCC. This study establishes a tumor-suppressive role of PGM1 by regulating glucose trafficking and uncovers a novel regulatory mechanism of PGM1 expression. |
WOS研究方向 | Biochemistry & Molecular Biology ; Biology |
语种 | 英语 |
WOS记录号 | WOS:000449322300023 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3451] |
专题 | 生化所2018年发文 |
作者单位 | 1.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Pathol, Shanghai, Peoples R China; 2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Innovat Ctr Cell Signaling Network,State Key Lab, Shanghai, Peoples R China; 3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai, Peoples R China; 4.First Affiliated Hosp, Wenzhou Med Coll, Dept Radiat Oncol, Wenzhou, Zhejiang, Peoples R China; 5.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 3, Shanghai, Peoples R China; 6.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Oncol, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Jin, Guang-Zhi,Cong, Wen-Ming,Zhang, Yajuan,et al. Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking[J]. PLOS BIOLOGY,2018,16(10):-. |
APA | Jin, Guang-Zhi.,Cong, Wen-Ming.,Zhang, Yajuan.,Wang, Xiongjun.,Wu, Siyang.,...&Yu, Guanzhen.(2018).Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking.PLOS BIOLOGY,16(10),-. |
MLA | Jin, Guang-Zhi,et al."Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking".PLOS BIOLOGY 16.10(2018):-. |
入库方式: OAI收割
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