The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
文献类型:期刊论文
作者 | Shen, Jiajia1,2; Liu, Xiujun1,2; Wang, Zhen1,2; Li, Pengyu3; Shao, Xuejing4; Yang, Yang5; Hu, Ronggui5; Feng, Min6; Yu, Qiang6 |
刊名 | CANCER RESEARCH
![]() |
出版日期 | 2018 |
卷号 | 78期号:2页码:359-371 |
关键词 | Polycomb-group Proteins Ubiquitin Ligase Tumor-suppressor Prostate-cancer Stem-cells Expression Bmi1 Repression Regulators Stability |
ISSN号 | 0008-5472 |
DOI | 10.1158/0008-5472.CAN-17-1805 |
文献子类 | Article |
英文摘要 | As a component of the transcriptional repression complex 1 (PRC1), the ring finger protein RING1 participates in the epigenetic regulation in cancer. However, the contributions of RING1 to cancer etiology or development are unknown. In this study, we report that RING1 is a critical negative regulator of p53 homeostasis in human hepatocellular and colorectal carcinomas. RING1 acts as an E3 ubiquitin (Ub) ligase to directly interact with and ubiquitinate p53, resulting in its proteasome-dependent degradation. The RING domain of RING1 was required for its E3 Ub ligase activity. RING1 depletion inhibited the proliferation and survival of the p53 wild-type cancer cells by inducing cell-cycle arrest, apoptosis, and senescence, with only modest effects on p53-deficient cells. Its growth inhibitory effect was partially rescued by p53 silencing, suggesting an important role for the RING1-p53 complex in human cancer. In clinical specimens of hepatocellular carcinoma, RING1 upregulation was evident in association with poor clinical outcomes. Collectively, our results elucidate a novel PRC1-independent function of RING1 and provide a mechanistic rationale for its candidacy as a new prognostic marker and/or therapeutic target in human cancer. (C) 2017 AACR. |
电子版国际标准刊号 | 1538-7445 |
WOS研究方向 | Oncology |
语种 | 英语 |
WOS记录号 | WOS:000422875400006 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3494] ![]() |
专题 | 生化所2018年发文 |
通讯作者 | Wang, Zhen |
作者单位 | 1.Chinese Acad Med Sci, Inst Med Biotechnol, Dept Biochem, Beijing, Peoples R China; 2.Peking Union Med Coll, Beijing, Peoples R China; 3.Shandong Univ, Qilu Hosp, Jinan, Shandong, Peoples R China; 4.Zhejiang Univ, Sch Pharmaceut Sci, Inst Pharmacol & Toxicol, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou, Zhejiang, Peoples R China; 5.Chinese Acad Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai, Peoples R China; 6.Biopolis, Agcy Sci Technol & Res A STAR, Genome Inst Singapore, Canc Therapeut & Stratified Oncol, Singapore, Singapore |
推荐引用方式 GB/T 7714 | Shen, Jiajia,Liu, Xiujun,Wang, Zhen,et al. The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival[J]. CANCER RESEARCH,2018,78(2):359-371. |
APA | Shen, Jiajia.,Liu, Xiujun.,Wang, Zhen.,Li, Pengyu.,Shao, Xuejing.,...&Yu, Qiang.(2018).The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.CANCER RESEARCH,78(2),359-371. |
MLA | Shen, Jiajia,et al."The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival".CANCER RESEARCH 78.2(2018):359-371. |
入库方式: OAI收割
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。