中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival

文献类型:期刊论文

作者Shen, Jiajia1,2; Liu, Xiujun1,2; Wang, Zhen1,2; Li, Pengyu3; Shao, Xuejing4; Yang, Yang5; Hu, Ronggui5; Feng, Min6; Yu, Qiang6
刊名CANCER RESEARCH
出版日期2018
卷号78期号:2页码:359-371
关键词Polycomb-group Proteins Ubiquitin Ligase Tumor-suppressor Prostate-cancer Stem-cells Expression Bmi1 Repression Regulators Stability
ISSN号0008-5472
DOI10.1158/0008-5472.CAN-17-1805
文献子类Article
英文摘要

As a component of the transcriptional repression complex 1 (PRC1), the ring finger protein RING1 participates in the epigenetic regulation in cancer. However, the contributions of RING1 to cancer etiology or development are unknown. In this study, we report that RING1 is a critical negative regulator of p53 homeostasis in human hepatocellular and colorectal carcinomas. RING1 acts as an E3 ubiquitin (Ub) ligase to directly interact with and ubiquitinate p53, resulting in its proteasome-dependent degradation. The RING domain of RING1 was required for its E3 Ub ligase activity. RING1 depletion inhibited the proliferation and survival of the p53 wild-type cancer cells by inducing cell-cycle arrest, apoptosis, and senescence, with only modest effects on p53-deficient cells. Its growth inhibitory effect was partially rescued by p53 silencing, suggesting an important role for the RING1-p53 complex in human cancer. In clinical specimens of hepatocellular carcinoma, RING1 upregulation was evident in association with poor clinical outcomes. Collectively, our results elucidate a novel PRC1-independent function of RING1 and provide a mechanistic rationale for its candidacy as a new prognostic marker and/or therapeutic target in human cancer. (C) 2017 AACR.

电子版国际标准刊号1538-7445
WOS研究方向Oncology
语种英语
WOS记录号WOS:000422875400006
版本出版稿
源URL[http://202.127.25.143/handle/331003/3494]  
专题生化所2018年发文
通讯作者Wang, Zhen
作者单位1.Chinese Acad Med Sci, Inst Med Biotechnol, Dept Biochem, Beijing, Peoples R China;
2.Peking Union Med Coll, Beijing, Peoples R China;
3.Shandong Univ, Qilu Hosp, Jinan, Shandong, Peoples R China;
4.Zhejiang Univ, Sch Pharmaceut Sci, Inst Pharmacol & Toxicol, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou, Zhejiang, Peoples R China;
5.Chinese Acad Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai, Peoples R China;
6.Biopolis, Agcy Sci Technol & Res A STAR, Genome Inst Singapore, Canc Therapeut & Stratified Oncol, Singapore, Singapore
推荐引用方式
GB/T 7714
Shen, Jiajia,Liu, Xiujun,Wang, Zhen,et al. The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival[J]. CANCER RESEARCH,2018,78(2):359-371.
APA Shen, Jiajia.,Liu, Xiujun.,Wang, Zhen.,Li, Pengyu.,Shao, Xuejing.,...&Yu, Qiang.(2018).The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.CANCER RESEARCH,78(2),359-371.
MLA Shen, Jiajia,et al."The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival".CANCER RESEARCH 78.2(2018):359-371.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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