中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The oscillatory boundary conditions of different frequency bands in Parkinson's disease

文献类型:期刊论文

作者Hu, Bing1,2; Guo, Yu1; Diao, Xiyezi1; Guo, Heng1; Zhang, Jinsong2; Yu, Liang2; Dai, Hao2; Chen, Luonan2,3; Shi, Qianqian4
刊名JOURNAL OF THEORETICAL BIOLOGY
出版日期2018
卷号451期号:1页码:67-79
关键词Deep-brain-stimulation External Globus-pallidus Subthalamic Nucleus Neurons Mild Cognitive Impairment Gated Calcium-channels Basal Ganglia Essential Tremor Computational Model Beta-oscillations Response Characteristics
ISSN号0022-5193
DOI10.1016/j.jtbi.2018.04.040
文献子类Article
英文摘要

Parkinson's disease (PD) is a neurodegenerative disease that is common in the elderly population. The most important pathological change in PD is the degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain, which results in a decrease in the dopamine (DA) content of the striatum. The exact cause of this pathological change is still unknown. Numerous studies have shown that the evolution of PD is associated with abnormal oscillatory activities in the basal ganglia, with different oscillation frequency ranges, such as the typical beta band (13-30 Hz), the alpha band (8-12 Hz), the theta band (4-7 Hz) and the delta band (1-3 Hz). Although some studies have implied that abnormal interactions between the subthalamic nucleus (STN) and globus pallidus (GP) neurons may be a key factor required to induce these oscillations, the relative mechanism is still unclear. The effects of other nerve nuclei in the basal ganglia, such as the striatum, on these oscillations are still unknown. The thalamus and cortex both have close input and output relationships with the basal ganglia, and many previous studies have indicated that they may also exert effects on Parkinson's disease oscillation, but the mechanisms involved are unclear. In this paper, we built a corticothalamic-basal ganglia (CTBG) mean firing-rate model to explore the onset mechanisms of these different oscillation phenomena. We found that, in addition to the STN-GP network, Parkinson's disease oscillations may also be induced by changing the coupling strength and delays in other pathways. Different frequency bands appear in the oscillating region, and various boundary conditions are depicted in parameter diagrams. The onset mechanism is well explained both by the model and by the numerical simulation results. Therefore, this model provides a unifying framework for studying the mechanism of Parkinson's disease oscillations, and we hope that the results obtained in this work can inspire future experimental studies. (C) 2018 Elsevier Ltd. All rights reserved.

电子版国际标准刊号1095-8541
WOS研究方向Biology ; Mathematical & Computational Biology
语种英语
WOS记录号WOS:000434002000007
版本出版稿
源URL[http://202.127.25.143/handle/331003/3500]  
专题生化所2018年发文
上海生化细胞研究所_上海生科院生化细胞研究所
通讯作者Hu, Bing; Shi, Qianqian
作者单位1.Huazhong Agr Univ, Coll Sci, Dept Math & Stat, Inst Appl Math, Wuhan 430070, Hubei, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol,CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China;
3.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China;
4.Huazhong Agr Univ, Coll Informat, Wuhan 430070, Hubei, Peoples R China
推荐引用方式
GB/T 7714
Hu, Bing,Guo, Yu,Diao, Xiyezi,et al. The oscillatory boundary conditions of different frequency bands in Parkinson's disease[J]. JOURNAL OF THEORETICAL BIOLOGY,2018,451(1):67-79.
APA Hu, Bing.,Guo, Yu.,Diao, Xiyezi.,Guo, Heng.,Zhang, Jinsong.,...&Shi, Qianqian.(2018).The oscillatory boundary conditions of different frequency bands in Parkinson's disease.JOURNAL OF THEORETICAL BIOLOGY,451(1),67-79.
MLA Hu, Bing,et al."The oscillatory boundary conditions of different frequency bands in Parkinson's disease".JOURNAL OF THEORETICAL BIOLOGY 451.1(2018):67-79.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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