VCAM-1(+) macrophages guide the homing of HSPCs to a vascular niche
文献类型:期刊论文
作者 | Li, Dantong1,2,3; Xue, Wenzhi1; Li, Mei1,2,3; Dong, Mei1; Wang, Jianwei1; Wang, Xianda1; Li, Xiyue1; Chen, Kai1; Zhang, Wenjuan1; Wu, Shuang1 |
刊名 | NATURE |
出版日期 | 2018 |
卷号 | 564期号:7734页码:119-+ |
ISSN号 | 0028-0836 |
关键词 | Hematopoietic Stem-cells Alpha-4 Integrins Definitive Hematopoiesis Stem/progenitor Cells Adhesion Molecule-1 Aortic Endothelium Fetal Liver Zebrafish Blood Expression |
DOI | 10.1038/s41586-018-0709-7 |
文献子类 | Article |
英文摘要 | Haematopoietic stem and progenitor cells (HSPCs) give rise to all blood lineages that support the entire lifespan of vertebrates(1). After HSPCs emerge from endothelial cells within the developing dorsal aorta, homing allows the nascent cells to anchor in their niches for further expansion and differentiation(2-5). Unique niche microenvironments, composed of various blood vessels as units of microcirculation and other niche components such as stromal cells, regulate this process(6-9). However, the detailed architecture of the microenvironment and the mechanism for the regulation of HSPC homing remain unclear. Here, using advanced live imaging and a cell-labelling system, we perform high-resolution analyses of the HSPC homing in caudal haematopoietic tissue of zebrafish (equivalent to the fetal liver in mammals), and reveal the role of the vascular architecture in the regulation of HSPC retention. We identify a VCAM-1(+) macrophage-like niche cell population that patrols the inner surface of the venous plexus, interacts with HSPCs in an ITGA4-dependent manner, and directs HSPC retention. These cells, named 'usher cells', together with caudal venous capillaries and plexus, define retention hotspots within the homing microenvironment. Thus, the study provides insights into the mechanism of HSPC homing and reveals the essential role of a VCAM-1(+) macrophage population with patrolling behaviour in HSPC retention. |
电子版国际标准刊号 | 1476-4687 |
WOS研究方向 | Multidisciplinary Sciences |
语种 | 英语 |
WOS记录号 | WOS:000452269400052 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3511] |
专题 | 生化所2018年发文 上海生化细胞研究所_上海生科院生化细胞研究所 |
通讯作者 | Pan, Weijun |
作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Key Lab Tissue Microenvironm & Tumor,CAS Ctr Exce, Shanghai, Peoples R China; 2.SJTUSM, Key Lab Stem Cell Biol, Shanghai, Peoples R China; 3.Chinese Acad Sci, SIBS, Shanghai, Peoples R China; 4.Tongji Univ, Sch Med, Tongji Hosp, Dept Orthoped Surg, Shanghai, Peoples R China; 5.Chinese Acad Sci, Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing, Peoples R China; 6.Chinese Acad Sci, Univ Chinese Acad Sci, Key Lab Computat Biol,Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol,Shanghai Inst, Shanghai, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol, CAS Ctr Excellence Mol Cell Sci,Inst Biochem & Ce, Shanghai, Peoples R China; 8.Boston Childrens Hosp, Stem Cell Program, Boston, MA USA; 9.Boston Childrens Hosp, Div Hematol Oncol, Boston, MA USA; 10.Harvard Med Sch, Dana Farber Canc Inst, Boston, MA USA; |
推荐引用方式 GB/T 7714 | Li, Dantong,Xue, Wenzhi,Li, Mei,et al. VCAM-1(+) macrophages guide the homing of HSPCs to a vascular niche[J]. NATURE,2018,564(7734):119-+. |
APA | Li, Dantong.,Xue, Wenzhi.,Li, Mei.,Dong, Mei.,Wang, Jianwei.,...&Wu, Dianqing.(2018).VCAM-1(+) macrophages guide the homing of HSPCs to a vascular niche.NATURE,564(7734),119-+. |
MLA | Li, Dantong,et al."VCAM-1(+) macrophages guide the homing of HSPCs to a vascular niche".NATURE 564.7734(2018):119-+. |
入库方式: OAI收割
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