Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha
文献类型：期刊论文
| 作者 | Zhang, P. J.1,2 ; Han, J. B.2; Gao, X. G.2; He, C. B.2; Lu, Z. C.2
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| 刊名 | GENETICS AND MOLECULAR RESEARCH
 |
| 出版日期 | 2015 |
| 卷号 | 14期号:1页码:2055-2062 |
| 关键词 | Spotted Seal (Phoca Largha) Sequence Variation Mhc Drb Gene Duplication |
| DOI | 10.4238/2015.March.20.15 |
| 文献子类 | Article |
| 英文摘要 | The major histocompatibility complex (MHC) is one of the most important genetic systems associated with resistance to infectious diseases in vertebrates. The spotted seal (Phoca largha) is one of the most endangered species in China. In this study, we present the first step in the molecular characterization of a DRB-like locus in the spotted seal by analyzing the nucleotide sequence of the polymorphic exon 2 segments, a 288-nucleotide sequence. By examining the segment from a group of 41 individuals, 28 alleles were identified. No deletion, insertion, or exceptional stop codon was detected, suggesting that these alleles could be functional in vivo. The nucleotide and amino acid sequences of the segment both showed a relatively high level of similarity (nucleotides 97%; amino acids 98%) to those of Meles meles and Zalophus californianus. The high level of spotted seal MHC-DRB polymorphism revealed in the present study has not been reported for the Phocidae and could be a consequence of the small spotted seal population adapting to the Bohai Sea, which probably has a relatively high level of pathogens. |
| WOS关键词 | EVOLUTION ; SELECTION ; INSIGHT |
| 语种 | 英语 |
| WOS记录号 | WOS:000357192700055 |
| 版本 | 出版稿 |
| 源URL | [http://124.16.218.2:8080/handle/183446/507]  |
| 专题 | 深海科学研究部_深海生物学研究室_海洋哺乳动物与海洋生物声学研究组 |
| 作者单位 | 1.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Marine Mammal & Marine Bioacoust Lab, Sanya, Peoples R China 2.Liaoning Ocean & Fisheries Sci Res Inst, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, P. J.,Han, J. B.,Gao, X. G.,et al. Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(1):2055-2062. |
| APA | Zhang, P. J.,Han, J. B.,Gao, X. G.,He, C. B.,&Lu, Z. C..(2015).Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha.GENETICS AND MOLECULAR RESEARCH,14(1),2055-2062. |
| MLA | Zhang, P. J.,et al."Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha".GENETICS AND MOLECULAR RESEARCH 14.1(2015):2055-2062. |
入库方式： OAI收割
来源：深海科学与工程研究所
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