Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway
文献类型：期刊论文
| 作者 | Han, Zhuang1,2 ; Xu, Ying1,4; Sun, Jin6; Zhang, Gen5; Wang, Kai-Ling1,3,4; Qian, Pei-Yuan1,5; Wang, Chang-Yun3; Liu, Qing-Ai3; Shao, Chang-Lun3; Liu, Ling-Li5
|
| 刊名 | BIOFOULING
 |
| 出版日期 | 2016 |
| 卷号 | 32期号:1页码:35-44 |
| 关键词 | Cochliomycin a Antifouling Barnacle Nitric Oxide Cgmp Mechanism |
| DOI | 10.1080/08927014.2015.1121245 |
| 文献子类 | Article |
| 英文摘要 | Cochliomycin A is a compound with anti-barnacle settlement activity and low toxicity, but the molecular mechanism of the compound is unknown. Here, isobaric tags for the relative or absolute quantitation (iTRAQ) labeling proteomic method were applied to analyze changes in the proteome of Amphibalanus ( =Balanus) amphitrite cyprids in response to cochliomycin A treatment. Cochliomycin A affected the cytochrome P450, glutathione S-transferase (GST) and NO/cGMP pathways, among which the NO/cGMP pathway was considered to play a key role in barnacle larval settlement, while the cytochrome P450 and the GST pathways are mainly for detoxification. The results of real-time PCR further suggested the NO/cGMP pathway was activated in response to cochliomycin A. Larval settlement assays revealed that S-methylisothiourea sulfate (SMIS) and 1H-(1,2,4) oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) rescued cyprids from cochliomycin A-induced inhibition of larval settlement. The findings supported the hypothesis that cochliomycin A inhibited barnacle larval settlement by stimulating the NO/cGMP pathway. |
| URL标识 | 查看原文 |
| WOS关键词 | NITRIC-OXIDE ; ANTIFOULING COMPOUNDS ; BALANUS-AMPHITRITE ; METAMORPHOSIS ; HSP90 ; BUTENOLIDE ; MECHANISMS ; ATTACHMENT ; EXPRESSION ; SYSTEM |
| 语种 | 英语 |
| WOS记录号 | WOS:000368561300005 |
| 版本 | 出版稿 |
| 源URL | [http://ir.idsse.ac.cn/handle/183446/1346]  |
| 专题 | 深海科学研究部_深海生物学研究室_深海微生物活性物质研究组 |
| 作者单位 | 1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya, Peoples R China 3.Ocean Univ China, Key Lab Marine Drugs, Minist Educ China, Sch Med & Pharm, Qingdao, Peoples R China 4.Shenzhen Univ, Coll Life Sci, Shenzhen, Peoples R China 5.Hong Kong Univ Sci & Technol, Sch Sci, Environm Sci Program, Hong Kong, Hong Kong, Peoples R China 6.Hong Kong Baptist Univ, Dept Biol, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Zhuang,Xu, Ying,Sun, Jin,et al. Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway[J]. BIOFOULING,2016,32(1):35-44. |
| APA | Han, Zhuang.,Xu, Ying.,Sun, Jin.,Zhang, Gen.,Wang, Kai-Ling.,...&Liu, Ling-Li.(2016).Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway.BIOFOULING,32(1),35-44. |
| MLA | Han, Zhuang,et al."Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway".BIOFOULING 32.1(2016):35-44. |
入库方式： OAI收割
来源：深海科学与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。