Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity
文献类型：期刊论文
| 作者 | Liang, Aiye; Zhou, Xiaomian; Wang, Qiuyan; Liu, Xin; Liu, Xiaojun; Du, Yuguang; Wang, Keyi; Lin, Bingcheng |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2006-10-20 |
| 卷号 | 843期号:1页码:114-119 |
| 关键词 | carrageenan granulocyte colony-stimulating factor interaction capillary zone electrophoresis leukemia cells |
| 产权排序 | 1;1 |
| 通讯作者 | 林炳承 |
| 英文摘要 | the effects of carrageenans' structural features on its interaction with granulocyte colony-stimulating factor (g-csf) and on the growth and differentiation of a g-csf dependent leukemia cell line (nfs-60) were studied. x, l, and k carrageenans, with decreasing contents of sulfation, bound to g-csf with binding constants of (6.2 +/- 0.6) x 10(5) m-1, (7.4 +/- 0.5) x 10(5) m-1 and (6.0 +/- 0.4) x 10(5) m-1, and with 27.7 +/- 0.2, 17.4 +/- 0.1 and 8.4 +/- 0.1 binding sites, respectively. however, k carrageenan oligosaccharide had no affinity for g-csf. the three carrageenans significantly inhibited g-csf-induced growth of nfs-60 cells. the high sulfate content x carrageenan could also induce the maturation of the cells, but relatively low sulfate content l and k carrageenans could not. the results suggested that g-csf-carrageenan bindings were dependent on carrageenans' sulfate contents and chain lengths, which could also affect the growth and differentiation of nfs-60 cells. (c) 2006 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | colony-stimulating factor ; sulfated polysaccharides ; antiviral activity ; cell ; virus ; proteoglycans ; leukemia ; protein ; nfs-60 ; acid |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000241472400016 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/98073]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Acad Life SCi, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Aiye,Zhou, Xiaomian,Wang, Qiuyan,et al. Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2006,843(1):114-119. |
| APA | Liang, Aiye.,Zhou, Xiaomian.,Wang, Qiuyan.,Liu, Xin.,Liu, Xiaojun.,...&Lin, Bingcheng.(2006).Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity.journal of chromatography b-analytical technologies in the biomedical and life sciences,843(1),114-119. |
| MLA | Liang, Aiye,et al."Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity".journal of chromatography b-analytical technologies in the biomedical and life sciences 843.1(2006):114-119. |
入库方式： OAI收割
来源：大连化学物理研究所
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