Prediction of the deleterious nsSNPs in ABCB transporters
文献类型：期刊论文
| 作者 | Li, Yanhong; Wang, Yonghua; Li, Yan; Yang, Ling |
| 刊名 | febs letters
 |
| 出版日期 | 2006-12-22 |
| 卷号 | 580期号:30页码:6800-6806 |
| 关键词 | prediction deleterious nsSNPs ABCB transporters computational |
| 产权排序 | 1;1 |
| 通讯作者 | 杨凌 |
| 英文摘要 | the non-synonymous snps (nssnps) in coding regions, neutral or deleterious, could lead to the alteration of the function or structure of proteins. we have developed the computational models to analyze the deleterious nssnps in the transporters and predict ones in abcb (atp-binding cassette b) transporters of interest. the rpls (ridge partial least square) and lda (linear discriminant analysis) methods were applied to the problem, by training on a selection of datasets from a specified source, i.e., human transporters. the best combination of datasets and prediction attributes was ascertained. the prediction accuracy of the theoretical rpls model for the training and testing sets is 84.8%, and 80.4%, respectively (lda: 84.3'% and 80.4%), which indicates the models are reasonable and may be helpful for pharmacogenetics studies. (c) 2006 federation of european biochemical societies. published by elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; biophysics ; cell biology |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics ; cell biology |
| 关键词[WOS] | single-nucleotide polymorphisms ; accessible surface-areas ; support vector regression ; protein-coupled receptors ; solvent accessibility ; gene polymorphisms ; chinese patients ; p-glycoprotein ; tap2 gene ; mutations |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000243266600008 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/98183]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmceut Resource Discovery, Dalian 116023, Peoples R China 2.Dalian Univ Technol, Sch Chem Engn, Dalian 116012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yanhong,Wang, Yonghua,Li, Yan,et al. Prediction of the deleterious nsSNPs in ABCB transporters[J]. febs letters,2006,580(30):6800-6806. |
| APA | Li, Yanhong,Wang, Yonghua,Li, Yan,&Yang, Ling.(2006).Prediction of the deleterious nsSNPs in ABCB transporters.febs letters,580(30),6800-6806. |
| MLA | Li, Yanhong,et al."Prediction of the deleterious nsSNPs in ABCB transporters".febs letters 580.30(2006):6800-6806. |
入库方式： OAI收割
来源：大连化学物理研究所
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