Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus
文献类型：期刊论文
| 作者 | Hao, Da-Cheng; Sun, Jie; Furnes, Bjarte; Schlenk, Daniel; Hou, Zhen-Fang; Zhang, Ya-Ping; Yang, Sheng-Li; Yang, Ling |
| 刊名 | biochemical genetics
 |
| 出版日期 | 2006-08-01 |
| 卷号 | 44期号:7-8页码:391-407 |
| 关键词 | FMO3 polymorphism haplotype frequency linkage evolution |
| 产权排序 | 1;1 |
| 通讯作者 | 杨凌 |
| 英文摘要 | we analyzed flavin-containing monooxygenase 3 (fmo3) polymorphisms, haplotype structure, and linkage disequilibrium (ld) in 256 han chinese and 50 african-american individuals to compare their haplotype frequencies and ld with other world populations. for the han chinese, genotyping of three haplotype tag single nucleotide polymorphisms (e158k, v257m, and e308g) was performed by polymerase chain reaction (pcr)-restriction fragment length polymorphism. for the african-americans, genotyping of all coding exons was performed by modified pcr-single strand conformational polymorphism. haplotype frequencies, ld, and evolutionary rates were inferred and estimated computationally. there were significant differences in haplotype frequency distribution and ld pattern among han chinese, african-americans, and other world populations. four major haplotypes of han chinese were eve, kve, eme, and evg. two major haplotypes of african-americans were eve and kve. we found that sites 158 and 257 are in significant ld in both populations. this is the first report comparing fmo haplotypes and ld of han chinese with african-americans. the data presented here justify further pharmacogenetic studies for potentially optimizing recommended drug dosages and evaluating relationships with disease processes. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; genetics & heredity |
| 研究领域[WOS] | biochemistry & molecular biology ; genetics & heredity |
| 关键词[WOS] | flavin-containing monooxygenase ; familial adenomatous polyposis ; in-vivo ; n-oxidation ; caffeine metabolism ; population ; flavin-monooxygenase-3 ; identification ; discovery ; variants |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000242851100009 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/98265]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China 2.Dalian Med Univ, Dept Emergency Med, Dalian, Peoples R China 3.Univ Calif Riverside, Environm Toxicol Program, Riverside, CA 92521 USA 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Da-Cheng,Sun, Jie,Furnes, Bjarte,et al. Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus[J]. biochemical genetics,2006,44(7-8):391-407. |
| APA | Hao, Da-Cheng.,Sun, Jie.,Furnes, Bjarte.,Schlenk, Daniel.,Hou, Zhen-Fang.,...&Yang, Ling.(2006).Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus.biochemical genetics,44(7-8),391-407. |
| MLA | Hao, Da-Cheng,et al."Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus".biochemical genetics 44.7-8(2006):391-407. |
入库方式： OAI收割
来源：大连化学物理研究所
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