Hydrolytic kinetics of lithospermic acid B extracted from roots of Salvia miltiorrhiza
文献类型：期刊论文
| 作者 | Guo, Yong-Xue; Zhang, Dai-Jia; Wang, Hui; Xiu, Zhi-Long; Wang, Long-Xing; Xiao, Hong-Bin |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2007-01-17 |
| 卷号 | 43期号:2页码:435-439 |
| 关键词 | lithospermic acid B hydrolysis kinetics LC/MS |
| 产权排序 | 2;5 |
| 通讯作者 | zhi-long xiu |
| 英文摘要 | the hydrolytic kinetics of lithospermic acid b (lab) extracted from the roots of salvia miltiorrhiza (chinese herb: danshen) was investigated by using reversed-phase high-performance liquid chromatography (hplc) with uv-vis detection. the influences of initial drug concentration, ph and temperature on hydrolysis of lab were studied in aqueous solutions. the results showed that initial concentration of lab has no effect on the degradation rate at ph 2.0. the hydrolysis followed pseudo-first-order kinetics at 90 degrees c. the log k(obs)-ph profile indicated that the optimal stability range was at ph 2.0-5.0. the rate constant of overall hydrolysis as a function of temperature under the given conditions obeyed the arrhenius equation. analysis of the acid-induced degraded solution of lab by liquid chromatography-mass spectrometry (lc-ms) revealed at least four degradation products [m - h](-) ion at m/z 197, 137, 537 and 537, respectively. three of these degradation products, i.e. danshensu (dsu), protocatechuic aldehyde (pro), and lithospermic acid, were further identified by comparing the retention times with standard samples. according to the structure of lab and its hydrolysis behavior in solution, the other product was proposed to be the isomer of lithospermic acid. (c) 2006 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | liquid-chromatography ; mass-spectrometry ; magnesium ; rats ; degradation ; inhibition ; radix |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000243802700006 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/98327]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Yong-Xue,Zhang, Dai-Jia,Wang, Hui,et al. Hydrolytic kinetics of lithospermic acid B extracted from roots of Salvia miltiorrhiza[J]. journal of pharmaceutical and biomedical analysis,2007,43(2):435-439. |
| APA | Guo, Yong-Xue,Zhang, Dai-Jia,Wang, Hui,Xiu, Zhi-Long,Wang, Long-Xing,&Xiao, Hong-Bin.(2007).Hydrolytic kinetics of lithospermic acid B extracted from roots of Salvia miltiorrhiza.journal of pharmaceutical and biomedical analysis,43(2),435-439. |
| MLA | Guo, Yong-Xue,et al."Hydrolytic kinetics of lithospermic acid B extracted from roots of Salvia miltiorrhiza".journal of pharmaceutical and biomedical analysis 43.2(2007):435-439. |
入库方式： OAI收割
来源：大连化学物理研究所
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