Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Th1 cells within immune organ of mouse IgA nephropathy
文献类型：期刊论文
| 作者 | Jia, Lewen; Wang, Chang; Kong, Hongwei; Yang, Jun; Li, Fanglou; Lv, Shen; Xu, Guowang |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2007-01-17 |
| 卷号 | 43期号:2页码:646-654 |
| 关键词 | IgA nephropathy phospholipid PA-MSHA vaccine Th-2/Th-1 high performance liquid chromatography metabolic profiling |
| 产权排序 | 1;1 |
| 通讯作者 | 许国旺 |
| 英文摘要 | phospholipids as a class of important constituents in the biomembranes have been paid increasing attention in many fields. iga nephropathy is now generally known to be the most common form of primary glomerulonephritis in the world. however, phospholipids metabolism in iga nephropathy was not clear. until recently, there was no effective treatment available for patients with iga nephropathy. in this paper, effect of pa-msha vaccine on plasma phospholipid metabolic profile of mouse iga nephropathy was investigated using high performance liquid chromatography/mass spectrometry (hplums) and principal components analysis (pca). female balb/c mice were divided into four groups: model group, control group, pa-msha treatment group and medicine control group (dipyridamole + common threewingnut root). the experimental iga nephropathy model was established by the immunity combination method of oral bsa and injection of seb. it was found that combination of lc/ms technology with pca can be successfully applied to phospholipids profile analysis, clearly classify the model group and normal group, and pa-msha treatment group is closer to the normal control group than medicine control group. the result showed that th-2/th-1 (=cd4+cd30+/cd4+cd30-) of the model group is 20.70 +/- 3.57, which is significantly higher than that of the control group (1.34 +/- 0.14) (p < 0.001). the th-2/th-1 ratio of the pa-msha treatment group and the medicine control group are lower than that of the model group (p < 0.01). it is suggested that mouse iga nephropathy has the phospholipids metabolic abnormality, pa-msha vaccine cannot only regulate the abnormal phospholipids metabolism mouse with the iga nephropathy, but also correct the over unbalance of th-2/th-1 proportion. (c) 2006 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | trap mass-spectrometry ; human blood ; metabonomics ; identification ; urine ; spectroscopy ; recognition ; severity ; acid ; gene |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000243802700035 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/98775]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, Dalian 116011, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 1, Expt Ctr, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Lewen,Wang, Chang,Kong, Hongwei,et al. Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Th1 cells within immune organ of mouse IgA nephropathy[J]. journal of pharmaceutical and biomedical analysis,2007,43(2):646-654. |
| APA | Jia, Lewen.,Wang, Chang.,Kong, Hongwei.,Yang, Jun.,Li, Fanglou.,...&Xu, Guowang.(2007).Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Th1 cells within immune organ of mouse IgA nephropathy.journal of pharmaceutical and biomedical analysis,43(2),646-654. |
| MLA | Jia, Lewen,et al."Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Th1 cells within immune organ of mouse IgA nephropathy".journal of pharmaceutical and biomedical analysis 43.2(2007):646-654. |
入库方式： OAI收割
来源：大连化学物理研究所
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