Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis
文献类型：期刊论文
| 作者 | Gao, Peng; Shi, Chunyun; Tian, Jing; Shi, Xianzhe; Yuan, Kailong; Lu, Xin; Xu, Guowang |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2007-05-09 |
| 卷号 | 44期号:1页码:180-187 |
| 关键词 | capillary electrophoresis tricarboxylic acid cycle carboxylic acids antibiotic |
| 产权排序 | 1;1 |
| 通讯作者 | 许国旺 |
| 英文摘要 | metabolomics is a new branch of systems biology exerting its influence in many aspects. in order to appraise the effects of antibiotics on central carbon metabolism, a ce based method was set up. with this platform, we estimated the organic acid metabolite pools' fluctuation of escherichia coli and pseudomonas aeruginosa cultured under 11 different antibiotics' stimuli. multivariate data analysis showed that different antibiotics had clustered distributions for each strain and could be easily distinguished. genetic, metabolic and antibiotic mechanism differences could also be deduced by the aid of further correlation analysis. for p. aeruginosa, even synergy action amid antibiotics could be ascertained. (c) 2007 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | microbial metabolomics ; mass-spectrometry ; resistance ; chromatography ; mechanisms ; selection ; strains ; targets ; efflux ; drugs |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000246350100025 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/98787]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Peng,Shi, Chunyun,Tian, Jing,et al. Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis[J]. journal of pharmaceutical and biomedical analysis,2007,44(1):180-187. |
| APA | Gao, Peng.,Shi, Chunyun.,Tian, Jing.,Shi, Xianzhe.,Yuan, Kailong.,...&Xu, Guowang.(2007).Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis.journal of pharmaceutical and biomedical analysis,44(1),180-187. |
| MLA | Gao, Peng,et al."Investigation on response of the metabolites in tricarboxylic acid cycle of Escherichi coli and Pseudomonas aeruginosa to antibiotic perturbation by capillary electrophoresis".journal of pharmaceutical and biomedical analysis 44.1(2007):180-187. |
入库方式： OAI收割
来源：大连化学物理研究所
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