Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae
文献类型：期刊论文
| 作者 | Li, Qiurong; Zhang, Qiang; Wang, Meng; Liu, Fuzhong; Zhao, Sumin; Ma, Jian; Luo, Nan; Li, Ning; Li, Yousheng; Xu, Guowang |
| 刊名 | archives of biochemistry and biophysics
 |
| 出版日期 | 2007-10-15 |
| 卷号 | 466期号:2页码:250-259 |
| 关键词 | polyunsaturated fatty acids caveolae fatty acid composition phospholipids eNOS |
| 产权排序 | 2;5 |
| 通讯作者 | 黎介寿 |
| 英文摘要 | n - 3 polyunsaturated fatty acids are assumed to play an important role in the prevention and treatment of atherosclerosis. endothelial nitric-oxide synthase (enos) is responsible for cardiovascular homeostasis involving in regulation of vascular function, and the subcellular localization is critical for its activation. here we determined the effect of docosahexaenoic acid (dha, 22:6 n - 3) on distribution of enos and its activity. dha treatment markedly altered lipid environment of caveolae microdomains, which was coincided with selective displacement of caveolin-1 and enos from caveolae. akt was not detected in caveolae fractions and cam was distributed in both of caveolin-1-enriched membranes and non-caveolar fractions, whose distribution was unaffected by dha. these data demonstrated for the first time that dha altered caveolae microenvironment not only by modifying membrane lipid composition, but also by changing distribution of major structural proteins. dha-induced alterations in caveolae lipid/protein environment may be an important mechanism in the development of pathogenesis of atherosclerosis. (c) 2007 elsevier inc. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; biophysics |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics |
| 关键词[WOS] | polyunsaturated fatty-acids ; protein-kinase b ; eicosapentaenoic acid ; signal-transduction ; lipid-composition ; membrane domains ; binding domain ; blood-pressure ; activation ; localization |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000250067700012 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/98813]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China 2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China 3.Nanjing Univ, Sch Med, Nanjing 210093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qiurong,Zhang, Qiang,Wang, Meng,et al. Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae[J]. archives of biochemistry and biophysics,2007,466(2):250-259. |
| APA | Li, Qiurong.,Zhang, Qiang.,Wang, Meng.,Liu, Fuzhong.,Zhao, Sumin.,...&Li, Jieshou.(2007).Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae.archives of biochemistry and biophysics,466(2),250-259. |
| MLA | Li, Qiurong,et al."Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae".archives of biochemistry and biophysics 466.2(2007):250-259. |
入库方式： OAI收割
来源：大连化学物理研究所
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