The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
文献类型：期刊论文
| 作者 | Li, Senlin1,2; Hong, Ze1; Wang, Zhe1,3 ; Li, Fei3; Mei, Jiahao1; Huang, Lulu2; Lou, Xiwen4; Zhao, Simeng3; Song, Lihua1; Chen, Wei2
|
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2018-12-18 |
| 卷号 | 25期号:12页码:3405-+ |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2018.11.097 |
| 通讯作者 | Liu, Xing(xingliu@ips.ac.cn) ; Tan, Ninghua(nhtan@cpu.edu.cn) ; Wang, Chen(cwang1971@cpu.edu.cn) |
| 英文摘要 | cGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify effective lead compounds that specifically downregulate the pathway. We report here that astin C, a cyclopeptide isolated from the medicinal plant Aster tataricus, inhibits cGAS-STING signaling and the innate inflammatory responses triggered by cytosolic DNAs. Moreover, mice treated with astin C are more susceptible to HSV-1 infection. Consistently, astin C markedly attenuates the autoinflammatory responses in Trex1(-/-) BMDM cells and in Trex1(-/-) mouse autoimmune disease model. Mechanistically, astin C specifically blocks the recruitment of IRF3 onto the STING signalosome. Collectively, this study characterizes a STING-specific small-molecular inhibitor that may be applied for potentially manipulating the STING-mediated clinical diseases. |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000453826600015 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64662]  |
| 专题 | 中国科学院昆明植物研究所 |
| 通讯作者 | Liu, Xing; Tan, Ninghua; Wang, Chen |
| 作者单位 | 1.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Sch Life Sci & Technol, State Key Lab Nat Med, 639 Longmian Ave, Nanjing 211198, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol,Innovat Ctr Cell Signalin, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Senlin,Hong, Ze,Wang, Zhe,et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING[J]. CELL REPORTS,2018,25(12):3405-+. |
| APA | Li, Senlin.,Hong, Ze.,Wang, Zhe.,Li, Fei.,Mei, Jiahao.,...&Wang, Chen.(2018).The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.CELL REPORTS,25(12),3405-+. |
| MLA | Li, Senlin,et al."The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING".CELL REPORTS 25.12(2018):3405-+. |
入库方式： OAI收割
来源：昆明植物研究所
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