Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1
文献类型：期刊论文
| 作者 | Wang, Zhe ; Zhao, Simeng; Song, Lihua; Pu, Yuzhi; Wang, Qiang; Zeng, Guangzhi; Liu, Xing; Bai, Ming; Li, Shao; Gao, Fabao
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| 刊名 | CELL DEATH & DISEASE
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| 出版日期 | 2018 |
| 卷号 | 9页码:715 |
| ISSN号 | 2041-4889 |
| 英文摘要 | Rubiaceae-type cyclopeptides (RAs) are a type of plant cyclopeptides from the Rubia that have garnered significant attention owing to their unique bicyclic structures and amazing antitumour activities. Our recent work has shown that RAs suppress inflammation and angiogenesis and induce apoptosis. However, the underlying mechanism and targets remained unknown. Nuclear factor kappa B (NF-kappa B) signaling pathway plays a critical role in these biological processes, prompting us to investigate whether and how RAs affect this pathway. By screening compound libraries using NF-kappa B-dependent luciferase reporter, we observed that RA-V is the best NF-kappa B inhibitor. Further experiments demonstrated that RA-V interrupted the TAK1-TAB2 interaction and targeted TAK1 in this pathway. Moreover, RA-V prevented endotoxin shock and inhibited NF-kappa B activation and tumor growth in vivo. These findings clarify the mechanism of RAV on NF-kappa B pathway and might account for the majority of known bioactivities of RA-V, which will help RA-V develop as new antiinflammatory and antitumour therapies. |
| 语种 | 英语 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64729]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Zhe,Zhao, Simeng,Song, Lihua,et al. Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1[J]. CELL DEATH & DISEASE,2018,9:715. |
| APA | Wang, Zhe.,Zhao, Simeng.,Song, Lihua.,Pu, Yuzhi.,Wang, Qiang.,...&Tan, Ninghua.(2018).Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1.CELL DEATH & DISEASE,9,715. |
| MLA | Wang, Zhe,et al."Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1".CELL DEATH & DISEASE 9(2018):715. |
入库方式： OAI收割
来源：昆明植物研究所
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