Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents
文献类型：期刊论文
| 作者 | Chi, Xiao-Qian; Zi, Cheng-Ting; Li, Hong-Mei; Yang, Liu; Lv, Yong-Feng; Li, Jin-Yu; Hou, Bo; Ren, Fu-Cai; Hu, Jiang-Miao ; Zhou, Jun
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:72页码:41377-41388 |
| ISSN号 | 2046-2069 |
| 英文摘要 | In order to better understand the structure-activity relationship of mangostin, a series of xanthone derivatives based on -mangostin were designed and synthesized. All the compounds were evaluated for their cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) using MTT assays. Most of them showed cytotoxicity and most of all, compounds 1a and 2h showed the highest cytotoxic potency by HL-60 cancer cell lines with IC50 values of 5.96 M and 6.90 M respectively; compound 3e showed the highest cytotoxic potency against SMMC-7221 cancer cell line with IC50 values of 3.98 M; compounds 2e and 2m showed lower cytotoxicity but higher selectivity than -mangostin against HL-60 and SMMC-7221 cancer cell lines respectively. Structure-activity relationship analysis indicates that the maintenance of the isopentene group at C-8 is essential for the cytotoxic activity. |
| 语种 | 英语 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64752]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Chi, Xiao-Qian,Zi, Cheng-Ting,Li, Hong-Mei,et al. Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents[J]. RSC ADVANCES,2018,8(72):41377-41388. |
| APA | Chi, Xiao-Qian.,Zi, Cheng-Ting.,Li, Hong-Mei.,Yang, Liu.,Lv, Yong-Feng.,...&Zhou, Jun.(2018).Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents.RSC ADVANCES,8(72),41377-41388. |
| MLA | Chi, Xiao-Qian,et al."Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents".RSC ADVANCES 8.72(2018):41377-41388. |
入库方式： OAI收割
来源：昆明植物研究所
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