Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation
文献类型：期刊论文
| 作者 | Chen, Gang; Lin, Jiao; Zhang, Jie; Wu, Ya; Gu, Xuefan; Hao, Xiaojiang ; Zhang, Yu
|
| 刊名 | COMPTES RENDUS CHIMIE
 |
| 出版日期 | 2018 |
| 卷号 | 21期号:5页码:471-474 |
| 关键词 | Isatin 3-Ethyl-3-hydroxy-indole-2-one Antitumor Neuroprotection |
| ISSN号 | 1631-0748 |
| DOI | 10.1016/j.crci.2018.02.009 |
| 通讯作者 | Chen, Gang(gangchen@xsyu.edu.cn) ; Hao, Xiaojiang(xjhao@mail.kib.ac.cn) |
| 英文摘要 | In this study, a series of 3-ethyl-3-hydroxy-indole-2-ones were synthesized through the addition reaction of Et2Zn and N -substituted isatin by an autocatalytic process. The synthesized compounds were characterized by NMR spectroscopy and mass spectrometry, and the reaction mechanism was discussed. The antitumor and neuroprotection activities of these compounds were evaluated. The results showed that several compounds display protection activity on H2O2-induced apoptosis of PC12 cells, which are more effective than that of (+/-)-alpha-tocopherol Vitamin E (VE). Moreover, these compounds also show antitumor activity against A549 and P388 cell lines. (C) 2018 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000439254800001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64766]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Chen, Gang,Lin, Jiao,Zhang, Jie,et al. Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation[J]. COMPTES RENDUS CHIMIE,2018,21(5):471-474. |
| APA | Chen, Gang.,Lin, Jiao.,Zhang, Jie.,Wu, Ya.,Gu, Xuefan.,...&Zhang, Yu.(2018).Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation.COMPTES RENDUS CHIMIE,21(5),471-474. |
| MLA | Chen, Gang,et al."Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation".COMPTES RENDUS CHIMIE 21.5(2018):471-474. |
入库方式： OAI收割
来源：昆明植物研究所
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