Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces
文献类型：期刊论文
| 作者 | Zhang, Zhouxin1,2; Cao, Pei1; Shang, Ning-Ning1,2; Yang, Jing1 ; Wang, Li1,2; Yan, Yijun1; Huang, Sheng-Xiong1
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2019-01-21 |
| 卷号 | 6期号:2页码:177-182 |
| ISSN号 | 2052-4129 |
| 英文摘要 | Chemical investigation of an endophytic Streptomyces strain led to the isolation of naphthomycin congeners 1-4. Compound 1 contains a unique phenalene scaffold with a bridged oxetane ring, which was confirmed to be a result of an intramolecular [2 + 2] cycloaddition between the olefin and the ketone in the known compound 4 by chemical conversion. 2 features an unprecedented acenaphthene moiety in the ansamycin class of polyketides. Possible biosynthetic pathways are proposed for 1-3. Compounds 1-3 were tested for cytotoxicity against selected human cancer cell lines and they showed moderate activity, with IC50 values ranging from 10.6 mu M to 32.5 mu M. |
| 资助项目 | National Natural Science Foundation of China[U1702285] ; National Natural Science Foundation of China[81522044] ; Applied Basic Research Foundation of Yunnan Province[2013HA022] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-SMC051] ; Yunnan Innovative Research Team for Discovery and Biosynthesis of Bioactive Natural Products[2018HC012] |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China ; Applied Basic Research Foundation of Yunnan Province ; Key Research Program of Frontier Sciences, CAS ; Yunnan Innovative Research Team for Discovery and Biosynthesis of Bioactive Natural Products |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64226]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Huang, Sheng-Xiong |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhouxin,Cao, Pei,Shang, Ning-Ning,et al. Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(2):177-182. |
| APA | Zhang, Zhouxin.,Cao, Pei.,Shang, Ning-Ning.,Yang, Jing.,Wang, Li.,...&Huang, Sheng-Xiong.(2019).Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces.ORGANIC CHEMISTRY FRONTIERS,6(2),177-182. |
| MLA | Zhang, Zhouxin,et al."Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces".ORGANIC CHEMISTRY FRONTIERS 6.2(2019):177-182. |
入库方式： OAI收割
来源：昆明植物研究所
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