Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity
文献类型：期刊论文
| 作者 | Guo, Kai1,2,3; Liu, Yan-Chun1,2 ; Liu, Yan1,2; Luo, Shi-Hong1,2; Li, Wen-Yuan1,2,3; Li, Xiao-Nian1,2; Li, Sheng-Hong1,2
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2019 |
| 卷号 | 157页码:43-52 |
| 关键词 | Leucosceptrum canum Lamiaceae Diterpenoids Abietane family Cytotoxic activity |
| ISSN号 | 0031-9422 |
| 英文摘要 | Twenty-four diterpenoids of abietane family, including thirteen undescribed compounds and eleven known ones, were isolated from the leaves of Leucosceptrurn canum. Their structures were elucidated by comprehensive spectroscopic analyses (including 1D and 2D-NMR and HRMS), and in the case of 15-hydroxy-abieta-8,11,13-trien-3-one by single-crystal X-ray diffraction. Their frameworks are highly diversified, involving normal abietane, 9,10-epoxy-9,10-seco-abietane, 18(4 -> 3)-abeo-abietane, 3,4-seco-18(4 -> 3)-abeo-abietane, and 16-norabietane. Selected compounds were evaluated for their cytotoxic activity against three human tumor cell lines, NCI-H1975, HepG2 and MCF-7. Among them, 3 beta-hydroxy-abieta-8,13-diene, 3 beta-hydroxy-abieta-8,11,13,15-tetraene, and 3 beta-hydroxy-9,10-epoxy-9,10-seco-abieta-8,11,13-triene exhibited moderate cytotoxicity against all three cell lines with IC50 values ranging from 8.11 to 50.73 mu M, while 3 alpha-hydroxy-abieta-8,11,13,15-tetraene, 3 beta-hydroxy-abieta-8,11,13,15-tetraen-7-one, and 15-hydroxy-18(4 -> 3)-abeo-abieta-3,8,11,13-tetraene were selectively active with IC50 values ranging from 28.80 to 71.29 mu M. |
| 资助项目 | National Science Fund for Distinguished Young Scholars[31525005] ; NSFC-Yunnan Joint Fund[U1502262] ; National Natural Science Foundation of China[31770390] ; National Natural Science Foundation of China[31770340] ; National Natural Science Foundation of China[31570362] ; Yunnan Innovative Research Team for Discovery and Biosynthesis of Bioactive Natural Products[2018HC012] |
| 语种 | 英语 |
| 资助机构 | National Science Fund for Distinguished Young Scholars ; NSFC-Yunnan Joint Fund ; National Natural Science Foundation of China ; Yunnan Innovative Research Team for Discovery and Biosynthesis of Bioactive Natural Products |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64303]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li, Sheng-Hong |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Kai,Liu, Yan-Chun,Liu, Yan,et al. Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity[J]. PHYTOCHEMISTRY,2019,157:43-52. |
| APA | Guo, Kai.,Liu, Yan-Chun.,Liu, Yan.,Luo, Shi-Hong.,Li, Wen-Yuan.,...&Li, Sheng-Hong.(2019).Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity.PHYTOCHEMISTRY,157,43-52. |
| MLA | Guo, Kai,et al."Diversified abietane family diterpenoids from the leaves of Leucosceptrurn canum and their cytotoxic activity".PHYTOCHEMISTRY 157(2019):43-52. |
入库方式： OAI收割
来源：昆明植物研究所
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