Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits
文献类型：期刊论文
| 作者 | Qin, Xu-Jie1 ; Jin, Ling-Yu1,2; Yu, Qian3; Liu, Hui1; Khan, Afsar4; Yan, Huan1; Hao, Xiao-Jiang1; An, Lin-Kun3; Liu, Hai-Yang1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2018-12-01 |
| 卷号 | 81期号:12页码:2638-2646 |
| ISSN号 | 0163-3864 |
| 英文摘要 | Ten new formyl-phloroglucinol terpene meroterpenoids, eucalypglobulusals A-J (1-10), and ten known analogues were isolated from Eucalyptus globulus fruits. The structures of 1-10 were determined by spectroscopic analysis, while their absolute configurations were established using calculated and experimental electronic circular dichroism (ECD) spectra. Eucalypglobulusal A was assigned as a new formyl-phloroglucinol- terpene meroterpenoid with a rearranged sesquiterpene skeleton, and an aldol condensation between C-3 and C-5 of the germacrene C moiety was proposed to be a key step in its putative biosynthetic pathway. Eucalypglobulusal F exhibited cytotoxicity against the human acute lymphoblastic cell line (CCRF-CEM) with an IC50 value of 3.3 mu M, while eucalypglobulusal A, eucarobustol C, macrocarpal A, macrocarpal B, and macrocarpal D exhibited DNA topoisomerase I (Top1) inhibition. The compounds eucalypglobulusal A and macrocarpal A act as Top1 catalytic inhibitors and delay Topl poison-mediated DNA double-strand damage. |
| 资助项目 | National Natural Science Foundation of China[31570363] ; National Natural Science Foundation of China[31600283] ; National Natural Science Foundation of China[81703668] ; National Natural Science Foundation of China[81373257] ; Scientific and Technological Projects of Yunnan Province[2017FB128] ; Major Biomedical Project of Yunnan Province[2018ZF005] ; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2017-KF06] ; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[S2017-ZZ08] ; CNGrid (China National Grid) |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China ; Scientific and Technological Projects of Yunnan Province ; Major Biomedical Project of Yunnan Province ; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China ; CNGrid (China National Grid) |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64318]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | An, Lin-Kun; Liu, Hai-Yang |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.West Yunnan Univ Appl Sci, Sch Tradit Dai Thai Med, Jinghong 666100, Peoples R China 3.Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem & Chem Biol, Guangzhou 510006, Guangdong, Peoples R China 4.COMSATS Univ Islamabad, Dept Chem, Abbottabad Campus, Abbottabad 22060, Pakistan |
| 推荐引用方式 GB/T 7714 | Qin, Xu-Jie,Jin, Ling-Yu,Yu, Qian,et al. Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(12):2638-2646. |
| APA | Qin, Xu-Jie.,Jin, Ling-Yu.,Yu, Qian.,Liu, Hui.,Khan, Afsar.,...&Liu, Hai-Yang.(2018).Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits.JOURNAL OF NATURAL PRODUCTS,81(12),2638-2646. |
| MLA | Qin, Xu-Jie,et al."Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits".JOURNAL OF NATURAL PRODUCTS 81.12(2018):2638-2646. |
入库方式： OAI收割
来源：昆明植物研究所
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